de Waal Koert, Petoello Enrico, Crendal Edward, Phad Nilkant
John Hunter Children's Hospital, department of neonatology, Newcastle NSW, Australia and the University of Newcastle, Newcastle, NSW, Australia.
J Perinatol. 2025 May 17. doi: 10.1038/s41372-025-02278-1.
Diastolic dysfunction often precedes systolic dysfunction and provides opportunity for management strategies. We aim to present reference ranges for diastolic function parameters in stable preterm infants at 2 timepoints.
Ultrasound scans of clinically stable preterm infants < 30 weeks gestation with no antenatal or postnatal complications were analysed for left heart size, mitral blood flows, myocardial velocities and shortening during the early (3 to 21 days) and late (corrected gestation 34 to 37 weeks) neonatal period.
92 early scans and 64 late scans were included. Mitral blood flow and myocardial velocities increased with augmented atrial function leading to higher EA and e'a' ratios and with relatively high Ee' ratio.
We present reference values for many left ventricular multimodal diastolic ultrasound parameters in preterm infants with uncomplicated fetal and neonatal development to guide prospective studies that explore diastolic function and diastolic heart failure in preterm infants.
舒张功能障碍通常先于收缩功能障碍出现，并为管理策略提供了机会。我们旨在给出稳定的早产儿在两个时间点舒张功能参数的参考范围。
对孕周小于30周、无产前或产后并发症的临床稳定的早产儿进行超声扫描，分析其在新生儿早期（3至21天）和晚期（矫正孕周34至37周）的左心大小、二尖瓣血流、心肌速度和缩短情况。
纳入了92次早期扫描和64次晚期扫描。随着心房功能增强，二尖瓣血流和心肌速度增加，导致更高的EA和e'a'比值以及相对较高的Ee'比值。
我们给出了胎儿和新生儿发育无并发症的早产儿许多左心室多模式舒张超声参数的参考值，以指导探索早产儿舒张功能和舒张性心力衰竭的前瞻性研究。
