在甲酰甲硫氨酸-亮氨酸-苯丙氨酸刺激的人中性粒细胞中，肌醇磷酸的形成并不需要胞质游离钙离子浓度升高。
Inositol phosphate formation in fMet-Leu-Phe-stimulated human neutrophils does not require an increase in the cytosolic free Ca2+ concentration.
作者信息
Di Virgilio F, Vicentini L M, Treves S, Riz G, Pozzan T
出版信息
Biochem J. 1985 Jul 15;229(2):361-7. doi: 10.1042/bj2290361.
Abstract
The accumulation of inositol phosphates in myo-[3H]inositol-labelled human neutrophils stimulated with the chemotactic peptide fMet-Leu-Phe was measured. The challenge with the chemotactic peptide caused the generation of inositol monophosphate (InsP), inositol bisphosphate (InsP2) and inositol trisphosphate (InsP3). The formation of the three inositol phosphates followed a differential time course: InsP3 accumulated very rapidly and transiently, whereas InsP increased steadily for more than 2 min. Inositol phosphate formation was only partially decreased by procedures which prevented the fMet-Leu-Phe-dependent increase of cytosolic free Ca2+ concentration.
摘要
测定了用趋化肽fMet-Leu-Phe刺激的[3H]肌醇标记的人中性粒细胞中肌醇磷酸的积累。趋化肽刺激导致肌醇一磷酸（InsP）、肌醇二磷酸（InsP2）和肌醇三磷酸（InsP3）的生成。三种肌醇磷酸的形成遵循不同的时间进程：InsP3迅速且短暂地积累，而InsP在2分钟以上持续稳定增加。通过阻止fMet-Leu-Phe依赖的胞质游离Ca2+浓度升高的方法，肌醇磷酸的形成仅部分减少。
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