A novel oxidation of the carcinogen N-hydroxy-N-2-fluorenylacetamide catalyzed by peroxidase/H2O2/Br-.
作者信息
Ritter C L, Malejka-Giganti D
出版信息
Biochem Biophys Res Commun. 1985 Aug 30;131(1):174-81. doi: 10.1016/0006-291x(85)91786-3.
PMID:4038295
Abstract
N-Hydroxy-N-2-fluorenylacetamide, a proximate carcinogenic metabolite of N-2-fluorenylacetamide, is oxidized largely to 2-nitrosofluorene by lactoperoxidase or extract of peroxidative activity of rat uterus in an H2O2- and Br- -dependent reaction. Evidence is presented that the oxidizing species includes OBr- (HOBr). This novel oxidation may be involved in carcinogenesis by N-arylhydroxamic acids.
摘要
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