Chaki Chironjeet, De Taboada Luis, Tse Kwong Ming
Department of Mechanical and Product Design Engineering, Swinburne University of Technology, Melbourne, Australia.
Enovis, Lewisville, Texas, USA.
J Biophotonics. 2025 Jul;18(7):e202400164. doi: 10.1002/jbio.202400164. Epub 2025 May 19.
High-intensity laser at a wavelength of 1064 nm has gained significant attention in the field of therapeutic applications due to its potential to penetrate deeper. Continuous wave laser therapy, although effective, poses a challenge of elevated skin temperature. This study endeavors to explore the transition from continuous to pulsed laser, aiming to enhance light fluence in deep tissue while mitigating skin temperature rise. Investigating continuous versus pulsed wave in transdermal deep tissue light therapy, this research utilizes a high-intensity laser at 1064 nm to optimize fluence in deep muscle tissue of the human knee, minimizing absorption-driven skin temperature rise. Simulated parameters, including peak power (60 W), pulse width (2 ms), duty cycle (10%), frequency (50 Hz), as well as beam size of 20 mm, indicate that pulsed wave irradiation after 300 s achieved the lowest skin surface temperature (42.5°C) and the highest fluence (approximately 4.2 J/cm).
波长为1064纳米的高强度激光因其具有更深穿透潜力而在治疗应用领域受到广泛关注。连续波激光疗法虽然有效，但存在皮肤温度升高的问题。本研究旨在探索从连续激光向脉冲激光的转变，以提高深部组织的光通量，同时减轻皮肤温度升高。在经皮深部组织光疗中研究连续波与脉冲波，本研究使用1064纳米的高强度激光来优化人体膝盖深部肌肉组织中的光通量，将吸收驱动的皮肤温度升高降至最低。模拟参数包括峰值功率（60瓦）、脉冲宽度（2毫秒）、占空比（10%）、频率（50赫兹）以及20毫米的光束尺寸，结果表明，300秒后脉冲波照射实现了最低的皮肤表面温度（42.5°C）和最高的光通量（约4.2焦耳/平方厘米）。
