Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas.
Kansas State Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas.
Am J Vet Res. 2022 May 8;83(6):ajvr.21.11.0186. doi: 10.2460/ajvr.21.11.0186.
To evaluate IV iron sucrose safety and impact on hematologic and iron indices in healthy cats.
5 healthy research cats.
Cats were administered iron sucrose (0.5 mg/kg, IV) over 30 minutes. Monitoring for acute reactions (temperature, heart rate, respiratory rate, and blood pressure) was performed every 5 minutes during injection and every 15 minutes for an additional hour. Baseline, 24-hour, and 1-, 2-, and 3-week postinjection measurements of CBC with reticulocyte indices, iron panel (ferritin, total iron-binding capacity, and iron), calculated transferrin saturation (TSAT), and serum amyloid A (SAA) concentration were performed.
No cat experienced an acute drug reaction. SAA concentration was increased at 24 hours versus baseline. TSAT and ferritin decreased over time, with 3 cats developing concurrent functional iron deficiency (FID) and anemia. Hct (Spearman correlation [rs] = 0.805), hemoglobin (rs = 0.770), and reticulocyte hemoglobin content (rs = 0.581) correlated with TSAT.
IV iron sucrose was well tolerated in healthy cats but was associated with transient increase in the systemic inflammatory marker SAA. Efficacy evaluation of dose based on iron deficit is needed in sick cats. Despite cumulative blood draw volume below recommended limits, anemia and FID were observed, which has important implications for experimental designs and serial hematologic monitoring. Further evaluation of inflammatory response to IV iron sucrose administration is warranted.
评估静脉注射蔗糖铁在健康猫中的安全性及其对血液学和铁指标的影响。
5 只健康的研究用猫。
猫以 0.5mg/kg 的剂量静脉注射蔗糖铁，持续 30 分钟。在注射过程中每 5 分钟监测一次急性反应（体温、心率、呼吸频率和血压），在随后的 1 小时内每 15 分钟监测一次。在基线、注射后 24 小时、1 周、2 周和 3 周时，进行全血细胞计数和网织红细胞指数、铁谱（血清铁蛋白、总铁结合力和铁）、计算转铁蛋白饱和度（TSAT）和血清淀粉样蛋白 A（SAA）浓度的测定。
没有猫出现急性药物反应。与基线相比，SAA 浓度在注射后 24 小时升高。TSAT 和血清铁蛋白随时间推移而降低，其中 3 只猫同时出现功能性缺铁（FID）和贫血。Hct（Spearman 相关系数 [rs] = 0.805）、血红蛋白（rs = 0.770）和网织红细胞血红蛋白含量（rs = 0.581）与 TSAT 相关。
静脉注射蔗糖铁在健康猫中耐受良好，但与全身性炎症标志物 SAA 的短暂升高有关。需要对患病猫基于铁缺乏量的剂量疗效进行评估。尽管采血总量低于推荐限度，但仍观察到贫血和 FID，这对实验设计和连续血液学监测具有重要意义。需要进一步评估静脉注射蔗糖铁给药后的炎症反应。
