Wang Juan, Tian Zan, Wang Jiaomin
Department of Obstetrics and Gynecology, Tongzhou Maternal and Child Health Hospital of Beijing Beijing 101100, China.
Department of Medicine, Tongzhou Maternal & Child Health Hospital of Beijing Beijing 101100, China.
Am J Transl Res. 2025 Apr 15;17(4):2992-3000. doi: 10.62347/GGVR2248. eCollection 2025.
To identify the risk factors for persistent HR-HPV infection in patients with cervical intraepithelial neoplasia (CIN).
A total of 312 patients with cervical intraepithelial neoplasia were followed up for six months. Among them, 164 patients with persistent HPV infection during re-examination were categorized into the persistent infection group, while 148 patients with negative HPV results were classified into the negative conversion group.
Multivariate logistic regression analyses identified the following independent risk factors for persistent HR-HPV infection: age ≥50 years (95% CI: 3.037-11.447; P<0.001), multiple HPV infections (95% CI: 4.250-18.417; P<0.001), HPV viral load ≥100 (95% CI: 1.529-5.673; P=0.001), reproductive tract inflammation (95% CI: 1.186-4.696; P=0.014), and thyroid dysfunction (95% CI: 8.346-17.207; P<0.001). A prediction model was developed based on the logistic regression analysis: Logit(P) = -102.56 + (age × 1.774) + (HPV multiple infections × 2.180) + (HPV viral load ≥100 × 1.080) + (reproductive tract inflammation × 0.859) + (thyroid dysfunction × 3.650). Receiver operating characteristic (ROC) curve analysis showed an area under the curve (AUC) of 0.800 for the model in predicting persistent high-risk HPV infection, with sensitivity of 81.00% and specificity of 79.46%.
Age ≥50 years, multiple HPV infections, HPV viral load ≥100, reproductive tract inflammation, and thyroid dysfunction are independent risk factors for persistent high-risk HPV infection in patients with CIN.
确定宫颈上皮内瘤变（CIN）患者持续性高危型人乳头瘤病毒（HR-HPV）感染的危险因素。
对312例宫颈上皮内瘤变患者进行为期6个月的随访。其中，复查时164例HPV持续感染患者被归入持续感染组，148例HPV结果为阴性的患者被归入转阴组。
多因素logistic回归分析确定了以下持续性HR-HPV感染的独立危险因素：年龄≥50岁（95%置信区间：3.037 - 11.447；P<0.001）、多种HPV感染（95%置信区间：4.250 - 18.417；P<0.001）、HPV病毒载量≥100（95%置信区间：1.529 - 5.673；P = 0.001）、生殖道炎症（95%置信区间：1.186 - 4.696；P = 0.014）以及甲状腺功能障碍（95%置信区间：8.346 - 17.207；P<0.001）。基于logistic回归分析建立了一个预测模型：Logit(P) = -102.56 +（年龄×1.774）+（HPV多种感染×2.180）+（HPV病毒载量≥100×1.080）+（生殖道炎症×0.859）+（甲状腺功能障碍×3.650）。受试者工作特征（ROC）曲线分析显示，该模型预测持续性高危型HPV感染的曲线下面积（AUC）为0.800，灵敏度为81.00%，特异度为79.46%。
年龄≥50岁、多种HPV感染、HPV病毒载量≥100、生殖道炎症以及甲状腺功能障碍是CIN患者持续性高危型HPV感染的独立危险因素。
