Nejatpour Mona, Bayındır Oğuz, Duru Pelin, Torabfam Milad, Meriç Cem, Kurt Hasan, Yüce Meral, Bayazıt Mustafa Kemal
Sabancı University Nanotechnology Research and Application Center, Tuzla, İstanbul 34956, Turkey.
Faculty of Engineering and Natural Science, Sabancı University, İstanbul 34956, Turkey.
ACS Omega. 2025 May 1;10(18):18213-18224. doi: 10.1021/acsomega.4c03612. eCollection 2025 May 13.
Fast, energy-efficient, and continuous manufacturing of nanoparticles (NPs) with controlled size and distribution in polymer matrices is challenging. Herein, a microwave-powered dual-injection continuous flow reactor is presented to prepare silver NP (AgNP)/polycaprolactone (PCL) nanocomposites (AgNP/PCL NCs). Ultrasmall spherical AgNPs (US-AgNPs, 1.86 ± 0.77 nm) can be manufactured in the PCL matrix in less than 3 min at ∼35 °C by applying 60 W microwave power and a combined flow rate of 1.25:1.25 mL/min (Pump1:Pump2). The effect of NP size and amount on the thermal, optical, and antimicrobial properties and the crystallinity of NCs are discussed. The NC crystallinity is independent of the NP's size and amount, while the NC film roughness is highly dependent on NP size. The antibacterial activity of the US-AgNPs-containing NC toward (∼98.2%), (∼98.2%), and (∼99.1%) is higher than big AgNP-containing NCs (82.3%, 85.7%, and 92.3%, respectively), signifying a strong NP size dependency instead of Ag concentration.
在聚合物基质中快速、节能且连续地制造尺寸和分布可控的纳米颗粒(NP)具有挑战性。在此,我们展示了一种微波驱动的双注射连续流动反应器,用于制备银纳米颗粒(AgNP)/聚己内酯(PCL)纳米复合材料(AgNP/PCL NCs)。通过施加60 W微波功率和1.25:1.25 mL/min(泵1:泵2)的组合流速,可在约35°C下于不到3分钟内在PCL基质中制造出超小的球形AgNP(US-AgNP,1.86±0.77 nm)。讨论了NP尺寸和数量对NCs的热、光学和抗菌性能以及结晶度的影响。NCs的结晶度与NP的尺寸和数量无关,而NC薄膜粗糙度高度依赖于NP尺寸。含US-AgNP的NC对大肠杆菌(98.2%)、金黄色葡萄球菌(98.2%)和白色念珠菌(~99.1%)的抗菌活性高于含大尺寸AgNP的NCs(分别为82.3%、85.7%和92.3%),这表明抗菌活性强烈依赖于NP尺寸而非Ag浓度。