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银/聚（乳酸）纳米复合材料：制备、表征和抗菌活性。

Silver/poly (lactic acid) nanocomposites: preparation, characterization, and antibacterial activity.

机构信息

Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Selangor, Malaysia.

出版信息

Int J Nanomedicine. 2010 Sep 7;5:573-9. doi: 10.2147/ijn.s12007.

DOI:10.2147/ijn.s12007
PMID:20856832
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2939702/
Abstract

In this study, antibacterial characteristic of silver/poly (lactic acid) nanocomposite (Ag/PLA-NC) films was investigated, while silver nanoparticles (Ag-NPs) were synthesized into biodegradable PLA via chemical reduction method in diphase solvent. Silver nitrate and sodium borohydride were respectively used as a silver precursor and reducing agent in the PLA, which acted as a polymeric matrix and stabilizer. Meanwhile, the properties of Ag/PLA-NCs were studied as a function of the Ag-NP weight percentages (8, 16, and 32 wt% respectively), in relation to the use of PLA. The morphology of the Ag/PLA-NC films and the distribution of the Ag-NPs were also characterized. The silver ions released from the Ag/PLA-NC films and their antibacterial activities were scrutinized. The antibacterial activities of the Ag/PLA-NC films were examined against Gram-negative bacteria (Escherichia coli and Vibrio parahaemolyticus) and Gram-positive bacteria (Staphylococcus aureus) by diffusion method using Muller-Hinton agar. The results indicated that Ag/PLA-NC films possessed a strong antibacterial activity with the increase in the percentage of Ag-NPs in the PLA. Thus, Ag/PLA-NC films can be used as an antibacterial scaffold for tissue engineering and medical application.

摘要

本研究考察了银/聚乳酸纳米复合材料（Ag/PLA-NC）薄膜的抗菌特性，通过两相溶剂中的化学还原法将银纳米粒子（Ag-NPs）合成到可生物降解的 PLA 中。硝酸银和硼氢化钠分别用作 PLA 中的银前体和还原剂，起到聚合物基质和稳定剂的作用。同时，还研究了 Ag/PLA-NC 的性能，作为 Ag-NP 重量百分比（分别为 8、16 和 32wt%）的函数，与 PLA 的使用有关。Ag/PLA-NC 薄膜的形貌和 Ag-NP 的分布也进行了表征。还研究了 Ag/PLA-NC 薄膜中释放的银离子及其抗菌活性。采用 Muller-Hinton 琼脂扩散法，研究了 Ag/PLA-NC 薄膜对革兰氏阴性菌（大肠杆菌和副溶血弧菌）和革兰氏阳性菌（金黄色葡萄球菌）的抗菌活性。结果表明，随着 PLA 中 Ag-NPs 百分比的增加，Ag/PLA-NC 薄膜具有很强的抗菌活性。因此，Ag/PLA-NC 薄膜可作为组织工程和医学应用的抗菌支架。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa88/2939702/8e4824bd9cdb/ijn-5-573f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa88/2939702/4158012656a3/ijn-5-573f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa88/2939702/c694394e2afb/ijn-5-573f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa88/2939702/fe374804beca/ijn-5-573f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa88/2939702/7e5336af8ed1/ijn-5-573f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa88/2939702/e761191f2b7a/ijn-5-573f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa88/2939702/8e4824bd9cdb/ijn-5-573f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa88/2939702/4158012656a3/ijn-5-573f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa88/2939702/c694394e2afb/ijn-5-573f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa88/2939702/fe374804beca/ijn-5-573f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa88/2939702/7e5336af8ed1/ijn-5-573f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa88/2939702/e761191f2b7a/ijn-5-573f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa88/2939702/8e4824bd9cdb/ijn-5-573f6.jpg

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