外泌体在心血管疾病中的作用：心肌细胞间通讯的关键调节因子
Role of Exosomes in Cardiovascular Disease: A Key Regulator of Intercellular Communication in Cardiomyocytes.
作者信息
Li Liuxin, Zheng Zhidong, Lan Wenyu, Tang Nan, Zhang Deju, Ling Jitao, Wu Yuting, Yang Pingping, Fu Linhua, Liu Jianping, Zhang Jing, Yu Peng, Huang Tieqiu
机构信息
Department of Endocrinology and Metabolism, second Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China, The second Clinical Medical College, Nanchang University, Nanchang 330006, Republic of China.
The Second Clinical Medical College of Nanchang University, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China.
出版信息
ACS Omega. 2025 May 5;10(18):18145-18169. doi: 10.1021/acsomega.4c11423. eCollection 2025 May 13.
In the cardiovascular system, different types of cardiovascular cells can secrete specific exosomes and participate in the maintenance of cardiovascular function and the occurrence and development of diseases. Exosomes carry biologically active substances such as proteins and nucleic acids from cells of origin and can be used as biomarkers for disease diagnosis and prognosis assessment. In addition, exosome-mediated intercellular communication plays a key role in the occurrence and development of cardiovascular diseases and has become a potential therapeutic target. This article emphasizes the importance of understanding the mechanism of exosomes in cardiovascular diseases and systematically details the current understanding of exosomes as regulators of intercellular communication in cardiomyocytes, providing a basis for future research and therapeutic intervention.
在心血管系统中，不同类型的心血管细胞可分泌特定的外泌体，并参与心血管功能的维持以及疾病的发生发展。外泌体携带来自其来源细胞的蛋白质和核酸等生物活性物质，可用作疾病诊断和预后评估的生物标志物。此外，外泌体介导的细胞间通讯在心血管疾病的发生发展中起关键作用，并已成为潜在的治疗靶点。本文强调了了解外泌体在心血管疾病中的作用机制的重要性，并系统地详述了目前对外泌体作为心肌细胞间通讯调节因子的认识，为未来的研究和治疗干预提供依据。
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