[兔κ轻链的进化：等位基因形式之间的多个替换]
[Evolution of the rabbit kappa light chain: multiple substitutions between allelic forms].
作者信息
Strosberg A D, Janssens L
出版信息
Ann Immunol (Paris). 1977 Jan-Mar;128(1-2):351-3.
PMID:403852
Abstract
The partial amino acid sequence of the rabbit IgG light chain constant region of allotype b6 was determined by analyzing tryptic digests. The comparison of available data on b4, b5, b6 and b9 constant region sequences reveal multiple differences ranging from 35% between b4 and b9 or between b6 and b9 chains, to 24% between b4 and b6 chains. This large number of substitutions suggests an early divergence of the b constant region structural genes into to-day's four polymorphic forms.
摘要
通过分析胰蛋白酶消化产物，确定了同种异型b6兔IgG轻链恒定区的部分氨基酸序列。对b4、b5、b6和b9恒定区序列的现有数据进行比较，发现存在多种差异，b4和b9之间或b6和b9链之间的差异为35%，b4和b6链之间的差异为24%。大量的替换表明b恒定区结构基因早期分化为如今的四种多态形式。
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