Pantoja Lucas Villar Pedrosa Silva, Fonseca Emily Christie Maia, Souza-Junior Fábio José Coelho, da Conceição Brenda Costa, Farias Sarah Viana, da Silva Joyce Kelly R, Maia José Guilherme Soares, Silva Pedro Iuri Castro, Freitas Jofre Jacob Silva, Prediger Rui Daniel, Campos Daniele Luz, Fontes-Júnior Enéas Andrade, Maia Cristiane Socorro Ferraz
Laboratório de Farmacologia da Inflamação e do Comportamento, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, Para, Brazil.
Laboratório de Biotecnologia de Enzimas e Biotransformações, Universidade Federal do Pará, Belém, Para, Brazil.
Front Pharmacol. 2025 May 2;16:1552295. doi: 10.3389/fphar.2025.1552295. eCollection 2025.
Neurologic and neuropsychiatric disorders are complex, with common pathophysiological mechanisms associated with inflammation, oxidative stress, and vascular damage. These shared features have stimulated interest in bioactive compounds with neuropharmacological potential. In this regard, the 1-Nitro-2-Phenylethane (1N2PE) emerges as a promissory compound to act on the multiple via of brain disturbances. However, its neuropharmacological mechanisms of action remain largely unknown. We aim to provide a comprehensive overview of the scarce literature on the effects of 1N2PE in brain disorders to highlight the importance of further research into the mechanisms of action and its potential applications in the field of neurology and psychiatry, focusing on the anti-inflammatory and antioxidant properties. The 1N2PE exhibits neuroprotective properties, including anti-inflammatory, antioxidant, and cholinergic-enhancing effects, which together may underlie its potential therapeutic benefits for various neuropsychiatric and neurological disorders, such as depression, anxiety, seizures, and cognitive impairments. This review compiles literature on 1N2PE potential central nervous system activities, highlighting its therapeutic potential in treating behavioral and neurological disorders. Despite promising findings, further research is essential to fully understand 1N2PE as a novel therapeutic agent.
神经和神经精神疾病很复杂，具有与炎症、氧化应激和血管损伤相关的共同病理生理机制。这些共同特征激发了人们对具有神经药理学潜力的生物活性化合物的兴趣。在这方面，1-硝基-2-苯乙烷（1N2PE）成为一种有望作用于多种脑功能障碍途径的化合物。然而，其神经药理学作用机制在很大程度上仍不清楚。我们旨在全面概述关于1N2PE对脑部疾病影响的稀少文献，以强调进一步研究其作用机制及其在神经学和精神病学领域潜在应用的重要性，重点关注其抗炎和抗氧化特性。1N2PE具有神经保护特性，包括抗炎、抗氧化和增强胆碱能作用，这些共同作用可能是其对各种神经精神和神经疾病（如抑郁症、焦虑症、癫痫和认知障碍）具有潜在治疗益处的基础。本综述汇编了关于1N2PE潜在中枢神经系统活性的文献，突出了其在治疗行为和神经疾病方面的治疗潜力。尽管有前景良好的研究结果，但进一步研究对于全面了解1N2PE作为一种新型治疗药物至关重要。
