Fukuda Taira, Kato Takashi, Kanazawa Yuta, Hirai Rina, Ishizaka Hayato, Tan Hideaki, Shibasaki Ikuko, Fukuda Hirotsugu, Toyoda Shigeru, Nakajima Toshiaki
Department of Health and Nutrition, Faculty of Human Sciences, University of Human Arts and Sciences, Saitama, JPN.
Department of Cardiovascular Surgery, School of Medicine, Dokkyo Medical University, Mibu, JPN.
Cureus. 2025 Apr 18;17(4):e82508. doi: 10.7759/cureus.82508. eCollection 2025 Apr.
The Society of Thoracic Surgeons surgical risk score (STS Score) is widely used to assess risk in cardiac surgery along with the Japan Score (Japan surgical risk score) in conjunction with the various biomarkers.
Preoperative blood tests were performed on 127 patients who subsequently underwent cardiovascular surgery (78 men, 49 women; mean age, 69.5 years). Serum levels of growth differentiation factor (GDF)-15, endothelin-1, and adiponectin were measured by enzyme-linked immunosorbent assay and used as independent variables in multivariate regression analysis with the STS Score or Japan Score as the dependent variable.
Serum levels of GDF-15, endothelin-1, and adiponectin correlated positively with the STS Score, the Japan Score, and the plasma brain natriuretic peptide (BNP) level, and correlated negatively with the estimated glomerular filtration rate (eGFR) and hemoglobin and albumin levels. After adjustment for age, sex, and body mass index, multivariate linear regression analysis showed that log (GDF-15) defined log (STS Score), and log (GDF-15) and log (endothelin-1) were independent factors defining log (Japan Score) (GDF-15: β = 0.372, p < 0.001; endothelin-1: β = 0.213, p = 0.016). eGFR and levels of hemoglobin and albumin defined log (GDF-15), and log (BNP) defined log (endothelin-1).
The STS Score and the Japan Score were associated with serum GDF-15 level in patients undergoing cardiovascular surgery. It is likely that the Japan Score had a stronger association with heart failure than the STS Score.
胸外科医师协会手术风险评分（STS评分）与日本评分（日本手术风险评分）以及各种生物标志物一起被广泛用于评估心脏手术风险。
对127例随后接受心血管手术的患者（78例男性，49例女性；平均年龄69.5岁）进行术前血液检查。通过酶联免疫吸附测定法测量生长分化因子（GDF）-15、内皮素-1和脂联素的血清水平，并将其作为多变量回归分析中的自变量，以STS评分或日本评分为因变量。
GDF-15、内皮素-1和脂联素的血清水平与STS评分、日本评分和血浆脑钠肽（BNP）水平呈正相关，与估计肾小球滤过率（eGFR）、血红蛋白和白蛋白水平呈负相关。在对年龄、性别和体重指数进行调整后，多变量线性回归分析显示，log（GDF-15）定义了log（STS评分），log（GDF-15）和log（内皮素-1）是定义log（日本评分）的独立因素（GDF-15：β = 0.372，p < 0.001；内皮素-1：β = 0.213，p = 0.016）。eGFR以及血红蛋白和白蛋白水平定义了log（GDF-15），log（BNP）定义了log（内皮素-1）。
在接受心血管手术的患者中，STS评分和日本评分与血清GDF-15水平相关。日本评分与心力衰竭的关联可能比STS评分更强。
