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同种异体骨应用于股骨远端骨折的功能及影像学结果:一项回顾性研究

Functional and Radiological Outcomes of Allograft Application in Distal Femur Fractures: A Retrospective Study.

作者信息

Kumar Ashwin, Venkataraman Sagar, S Nagakumar J, Thampi Gils

机构信息

Department of Orthopedics, Sri Devaraj Urs Medical College (SDUMC), Kolar, IND.

出版信息

Cureus. 2025 Apr 17;17(4):e82473. doi: 10.7759/cureus.82473. eCollection 2025 Apr.

Abstract

Background Distal femur fractures are complex injuries requiring surgical intervention, particularly in cases involving bone loss, comminution, or osteoporosis. While autografts remain the preferred option for bone grafting due to their osteogenic, osteoinductive, and osteoconductive properties, their use is often restricted due to donor-site morbidity, limited availability, and increased surgical time. Allografts provide an alternative, offering structural support without additional surgical site morbidity. This study evaluates the radiological and functional outcomes of allograft application in distal femur fractures. Methods A retrospective study was conducted at R. L. Jalappa Hospital, Kolar, analyzing 23 patients who underwent allograft-assisted distal femur fracture fixation between May 2023 and April 2024. The inclusion criteria were distal femur fractures requiring allograft augmentation, while exclusion criteria included pathological fractures, severe infections, and polytrauma patients. Radiological union was assessed using serial X-rays at three and six months, evaluating callus formation and cortical bridging. Pain relief was measured using the visual analog scale (VAS) at each follow-up. Functional recovery was evaluated using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC score), assessing pain, stiffness, and physical function. Results Radiological signs of union were achieved in most patients within three to six months. By three months, radiological healing was observed in 11 (47.8%) of cases, and by six months, 17 (73.9%) of patients achieved cortical union. Pain score improved significantly over time, with VAS scores decreasing from 6-8 at one month to 1-3 at six months. Functional recovery followed a similar pattern, with WOMAC scores improving from 65-80 at one month to 85-98 at six months, indicating substantial progress in joint mobility, weight-bearing ability, and pain reduction. Conclusion The findings suggest that allografts provide effective structural support and facilitate bone healing in distal femur fractures, particularly in cases with bone loss. Radiological union is slightly slower than the autografts, and the functional outcomes remain comparable. Allografts serve as a viable option for patients with large bone defects or contraindications for autograft harvesting.

摘要

背景

股骨远端骨折是复杂的损伤,需要手术干预,特别是在涉及骨缺损、粉碎或骨质疏松的情况下。由于自体骨具有成骨、骨诱导和骨传导特性,仍然是骨移植的首选,但由于供区并发症、可用性有限以及手术时间增加,其应用常常受到限制。同种异体骨提供了一种替代方案,可提供结构支撑且不会增加额外的手术部位并发症。本研究评估了同种异体骨应用于股骨远端骨折的影像学和功能结果。

方法

在科拉尔的R.L.贾拉帕医院进行了一项回顾性研究,分析了2023年5月至2024年4月期间接受同种异体骨辅助股骨远端骨折固定的23例患者。纳入标准为需要同种异体骨增强的股骨远端骨折,排除标准包括病理性骨折、严重感染和多发伤患者。在术后3个月和6个月时通过系列X线片评估影像学骨愈合情况,评估骨痂形成和皮质桥接情况。每次随访时使用视觉模拟量表(VAS)测量疼痛缓解情况。使用西安大略和麦克马斯特大学骨关节炎指数(WOMAC评分)评估功能恢复情况,评估疼痛、僵硬和身体功能。

结果

大多数患者在3至6个月内实现了影像学骨愈合迹象。到3个月时,11例(47.8%)病例观察到影像学愈合,到6个月时,17例(73.9%)患者实现皮质骨愈合。疼痛评分随时间显著改善,VAS评分从1个月时的6 - 8降至6个月时的1 - 3。功能恢复遵循类似模式,WOMAC评分从1个月时的65 - 80提高到6个月时的85 - 98,表明在关节活动度、负重能力和疼痛减轻方面取得了显著进展。

结论

研究结果表明,同种异体骨为股骨远端骨折提供了有效的结构支撑并促进骨愈合,特别是在有骨缺损的情况下。影像学骨愈合比自体骨稍慢,功能结果相当。同种异体骨是有大骨缺损或有自体骨采集禁忌证患者的可行选择。

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