Xie Zhaozhan, Zhang Xuecheng, Jia Hongling, Zhang Yongchen
School of Acupuncture-Moxibustion and Tuina, Shandong University of Chinese Medicine, Jinan, Shandong, China.
Department of Proctology, China-Japan Friendship Hospital, Beijing, China.
Front Psychiatry. 2025 May 2;16:1584306. doi: 10.3389/fpsyt.2025.1584306. eCollection 2025.
Male Sexual Dysfunction (MSD), comprising erectile dysfunction (ED), premature ejaculation, and hypoactive sexual desire disorder, exhibits an age-related prevalence affecting 50% of males beyond their fourth decade. Epidemiological studies demonstrate ED prevalence rates of 79.4% in general clinical populations. Beyond physiological manifestations, MSD with comorbid anxiety and depression exerts profound psychosocial impacts, potentially exacerbating pre-existing mental health conditions and impairing interpersonal relationships. Emerging evidence suggests Chinese Herbal Medicine (CHM) may offer therapeutic potential for addressing this clinical intersection. Therefore, this study will perform a systematic review and meta-analysis to assess the efficacy of various CHM interventions for MSD patients with comorbid anxiety and depression.
This study will systematically search four Chinese databases (China National Knowledge Infrastructure, Wanfang Database, China Biomedical Database, and VIP Database) and four international databases (PubMed, Web of Science, EMBASE, and Cochrane Library). Randomized controlled trials (RCTs) investigating CHM interventions for MSD with comorbid anxiety and depression will be identified. The retrieved studies will undergo rigorous screening and quality assessment using standardized tools.
The findings of this investigation will establish an evidence-based foundation for optimizing CHM therapeutic protocols in managing MSD with comorbid anxiety and depression.
This investigation will synthesize evidence-based data to evaluate therapeutic outcomes of various CHM modalities for MSD with comorbid anxiety and depression. Through comparative effectiveness analyses, the study aims to establish hierarchical treatment recommendations, enabling clinicians to optimize intervention strategies and facilitate personalized treatment selection in clinical practice.
https://www.crd.york.ac.uk/prospero, identifier CRD420250652254.
男性性功能障碍（MSD）包括勃起功能障碍（ED）、早泄和性欲减退障碍，其患病率与年龄相关，在40岁以上男性中，有50%受其影响。流行病学研究表明，在一般临床人群中，ED的患病率为79.4%。除了生理表现外，伴有焦虑和抑郁的MSD会产生深远的心理社会影响，可能会加剧已有的心理健康问题并损害人际关系。新出现的证据表明，中草药（CHM）可能为解决这一临床交叉问题提供治疗潜力。因此，本研究将进行系统评价和荟萃分析，以评估各种CHM干预措施对伴有焦虑和抑郁的MSD患者的疗效。
本研究将系统检索四个中文数据库（中国知网、万方数据库、中国生物医学数据库和维普数据库）和四个国际数据库（PubMed、Web of Science、EMBASE和Cochrane图书馆）。将识别调查CHM干预措施治疗伴有焦虑和抑郁的MSD的随机对照试验（RCT）。检索到的研究将使用标准化工具进行严格筛选和质量评估。
本调查结果将为优化CHM治疗方案以管理伴有焦虑和抑郁的MSD奠定循证基础。
本调查将综合循证数据，以评估各种CHM模式治疗伴有焦虑和抑郁的MSD的治疗效果。通过比较有效性分析，该研究旨在建立分层治疗建议，使临床医生能够优化干预策略，并在临床实践中促进个性化治疗选择。
