Plott Natalia, Rougraff Audra, Bose Paroma, Tolliver Kyla M, Waseem Shamaila, Hoskins Brett J
Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition Indiana University School of Medicine, Riley Hospital for Children at IU Health Indianapolis Indiana USA.
JPGN Rep. 2025 Feb 3;6(2):157-161. doi: 10.1002/jpr3.70000. eCollection 2025 May.
Pediatric upper gastrointestinal bleeding (UGIB) is a significant clinical concern, with a mortality rate of approximately 2%. Endoscopic management of UGIB in children includes various techniques such as injections, mechanical devices, thermal therapies, and topical agents. PuraStat®, a clear hemostatic gel, has been used in adults to create a physical barrier for hemostasis without obscuring the endoscopic view. However, its use in pediatric UGIB has not been well-documented. A review of four pediatric cases where PuraStat® was used to treat UGIB showed that it was applied as an adjunct to other hemostatic methods like clip placement or epinephrine injections, and in one case, as monotherapy for a large duodenal ulcer/site of recently contained perforation. The gel was easy to use, appeared to be beneficial, and was well-tolerated in this small cohort, although conclusions regarding its safety and efficacy are limited by the sample size.
小儿上消化道出血（UGIB）是一个重要的临床问题，死亡率约为2%。小儿UGIB的内镜治疗包括多种技术，如注射、机械装置、热疗法和局部用药。PuraStat®是一种透明的止血凝胶，已用于成人以形成物理止血屏障，且不影响内镜视野。然而，其在小儿UGIB中的应用尚无充分文献记载。一项对4例使用PuraStat®治疗小儿UGIB病例的回顾显示，它被用作夹子放置或肾上腺素注射等其他止血方法的辅助手段，在1例中，作为大的十二指肠溃疡/近期封闭穿孔部位的单一疗法。该凝胶使用方便，似乎有益，在这个小队列中耐受性良好，尽管关于其安全性和有效性的结论受样本量限制。
