Qiu Fanji, Li Jinfeng, Gan Liaoyan, Legerlotz Kirsten
Movement Biomechanics, Institute of Sport Sciences, Humboldt-Universität zu Berlin, Unter den Linden 6, 10099 Berlin, Germany.
Department of Kinesiology, Iowa State University, Ames, IA 50011, USA.
Prev Med Rep. 2025 Apr 28;54:103089. doi: 10.1016/j.pmedr.2025.103089. eCollection 2025 Jun.
In the context of global aging, the burden of metabolic diseases and arthritis is escalating, necessitating a more comprehensive understanding of the associations between these diseases. As modifiable factor the effect of lifestyle on the progression of arthritis also needs to be considered. Thus, this study aimed to identify the associations of the number of metabolic diseases (MDs) and lifestyle factors, with Rheumatoid Arthritis (RA) and Osteoarthritis (OA).
This is a cross analysis of data from European cohort collected between 2017 and 2021. The demographic information, lifestyle factors, and disease data were used for a prospective analysis to explore the impact of MDs on the prevalence of arthritis within the 4-year study period ( = 43,085). In addition, a cross-sectional analysis of 9th wave participants ( = 66,208) was conducted to investigate the relationship between lifestyle factors and arthritis. Cox regression and binary logistic regression models were employed to explore the relationships between various factors and arthritis.
About 6.52 % and 12.54 % participants developed RA and OA within the 4-year study period. Individuals with MDs exhibited a higher risk of new-onset arthritis compared to no-MDs participants. OA prevalence was positively associated with higher age, higher BMI, less physical activity (PA) and smoking. RA prevalence was positively associated with higher age, higher BMI and less PA.
There is a causal relationship between the number of MDs and new-onset Rheumatoid Arthritis and Osteoarthritis. Arthritis prevention programs should consider metabolic diseases as well as lifestyle factors in patients at risk.
在全球老龄化背景下，代谢性疾病和关节炎的负担不断加重，因此有必要更全面地了解这些疾病之间的关联。作为可改变的因素，生活方式对关节炎进展的影响也需要考虑。因此，本研究旨在确定代谢性疾病（MDs）的数量和生活方式因素与类风湿性关节炎（RA）和骨关节炎（OA）之间的关联。
这是一项对2017年至2021年期间收集的欧洲队列数据的交叉分析。人口统计学信息、生活方式因素和疾病数据用于前瞻性分析，以探讨在4年研究期内MDs对关节炎患病率的影响（n = 43,085）。此外，对第9波参与者（n = 66,208）进行横断面分析，以研究生活方式因素与关节炎之间的关系。采用Cox回归和二元逻辑回归模型来探讨各种因素与关节炎之间的关系。
在4年研究期内，约6.52%和12.54%的参与者患上了RA和OA。与无MDs的参与者相比，患有MDs的个体患新发关节炎的风险更高。OA患病率与较高年龄、较高体重指数、较少体力活动（PA）和吸烟呈正相关。RA患病率与较高年龄、较高体重指数和较少PA呈正相关。
MDs的数量与新发类风湿性关节炎和骨关节炎之间存在因果关系。关节炎预防项目应考虑代谢性疾病以及有风险患者的生活方式因素。
