Willhite C C, Chow F I, Taylor M J, Omaye S T
Food Chem Toxicol. 1985 Jan;23(1):51-4. doi: 10.1016/0278-6915(85)90220-0.
The absorption and elimination of all-trans-retinol in the plasma of rats and hamsters were studied after an oral dose of 45 mg/kg body weight. The hamsters exhibited a higher pretreatment mean circulating retinol concentration than rats maintained on an identical diet. The increase in plasma retinol after a single oral dose was much greater in hamsters than rats. The area under the plasma concentration v. time curve was approximately 60% greater for rats than for hamsters. The elimination half-times for rats were much longer than for hamsters. Plasma retinol uptake and disappearance were consistent with a two-compartment open model with first-order absorption.
给大鼠和仓鼠口服剂量为45毫克/千克体重的全反式视黄醇后，研究了其在血浆中的吸收和消除情况。在相同饮食条件下，仓鼠的预处理平均循环视黄醇浓度高于大鼠。单次口服给药后，仓鼠血浆视黄醇的增加幅度远大于大鼠。大鼠的血浆浓度-时间曲线下面积比仓鼠大约大60%。大鼠的消除半衰期比仓鼠长得多。血浆视黄醇的摄取和消失情况与具有一级吸收的二室开放模型一致。
