Quirk Alexis R, Schifferer Jenna K, Maki Katherine A, Robinson Austin T, Keirns Bryant H
Department of Nutrition and Health Science, Ball State University, Muncie, Indiana, United States.
Translational Biobehavioral and Health Disparities Branch, National Institutes of Health Clinical Center, Bethesda, Maryland, United States.
Am J Physiol Gastrointest Liver Physiol. 2025 Jul 1;329(1):G79-G87. doi: 10.1152/ajpgi.00120.2025. Epub 2025 May 19.
Intestinal hyperpermeability, which refers to translocation of microbial factors into the bloodstream, is associated with many chronic diseases. Increased intestinal permeability may contribute to the pathophysiology of these diseases by promoting systemic inflammation. Although early work on the health implications of increased intestinal permeability focused on diseases of the gastrointestinal tract, subsequent preclinical and cross-sectional data identified that various types of cardiometabolic and cardiovascular diseases (CVDs) are linked to gut barrier dysfunction. More recently, a body of epidemiological studies has emerged, indicating that elevated biomarkers of intestinal permeability are prospectively linked to incident CVD and CVD events, such as myocardial infarction and stroke, even after controlling for traditional CVD risk factors. In this brief review, we discuss gut barrier function in health and disease, highlight methodologies used to assess intestinal permeability, and review the emerging literature demonstrating that measures of intestinal permeability predict future CVD across several populations.
肠道高通透性是指微生物因子进入血液循环，它与许多慢性疾病相关。肠道通透性增加可能通过促进全身炎症反应而导致这些疾病的病理生理过程。尽管早期关于肠道通透性增加对健康影响的研究主要集中在胃肠道疾病，但随后的临床前和横断面数据表明，各种类型的心脏代谢和心血管疾病（CVD）都与肠道屏障功能障碍有关。最近，一系列流行病学研究表明，即使在控制了传统的CVD危险因素之后，肠道通透性升高的生物标志物仍与新发CVD以及心肌梗死和中风等CVD事件存在前瞻性关联。在这篇简短的综述中，我们讨论了健康和疾病状态下的肠道屏障功能，强调了用于评估肠道通透性的方法，并回顾了新出现的文献，这些文献表明肠道通透性测量可预测多个人群未来的CVD。
