Dou Shuangshuang, Huo Yunfei, Gao Minghui, Li Quanwei, Kou Buxin, Chai Mengyin, Liu Xiaoni
Beijing Institute of Hepatology, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.
Chin Med J (Engl). 2025 Jun 5;138(11):1313-1323. doi: 10.1097/CM9.0000000000003480. Epub 2025 May 19.
Liver cancer is one of the most common malignant tumors worldwide. Currently, the available treatment methods cannot fully control its recurrence and mortality rate. Establishing appropriate animal models for liver cancer is crucial for developing new treatment technologies and strategies. The patient-derived xenograft (PDX) model preserves the tumor's microenvironment and heterogeneity, which makes it advantageous for biological research, drug evaluation, personalized medicine, and other purposes. This article reviews the development, preparation techniques, application fields, and challenges of PDX models in liver cancer, providing insights for the research and exploration of PDX models in diagnostic and therapeutic strategies of liver cancer.
肝癌是全球最常见的恶性肿瘤之一。目前，现有的治疗方法无法完全控制其复发率和死亡率。建立合适的肝癌动物模型对于开发新的治疗技术和策略至关重要。患者来源的异种移植（PDX）模型保留了肿瘤的微环境和异质性，这使其在生物学研究、药物评估、个性化医疗等方面具有优势。本文综述了PDX模型在肝癌中的发展、制备技术、应用领域及挑战，为PDX模型在肝癌诊断和治疗策略中的研究与探索提供见解。
