西班牙65岁及以下新诊断2型糖尿病患者的血糖和体重控制：PRIORITY-T2D研究的见解

Glycaemic and Weight Control in People Aged 65 or Younger Newly Diagnosed with Type 2 Diabetes in Spain: Insights from the PRIORITY-T2D Study.

作者信息

Ortega Emilio, Redondo-Antón Jennifer, Díaz-Cerezo Silvia, Rubio-de Santos Miriam, Romera Irene

机构信息

Diabetes Unit, Department of Endocrinology and Nutrition, Hospital Clínic, C. de Villarroel, 170, L'Eixample, 08036, Barcelona, Spain.

Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Monforte de Lemos, 3-5, 28029, Madrid, Spain.

出版信息

Adv Ther. 2025 May 19. doi: 10.1007/s12325-025-03230-7.

DOI:10.1007/s12325-025-03230-7

PMID:40388088

Abstract

INTRODUCTION

The objective of this study was to determine the number of people within glycated haemoglobin (HbA1c) targets and achieving weight-loss goals during the first 5 years after type 2 diabetes (T2D) diagnosis and to explore the relationship between early weight loss and glycaemic control in routine care in Spain.

METHODS

This was an observational retrospective study using IQVIA's electronic medical record database, including adults aged ≤ 65 years newly diagnosed with T2D. Variables included baseline sociodemographic/clinical characteristics, yearly HbA1c and weight data, and treatment patterns. Descriptive statistics and regression analyses were used.

RESULTS

A total of 8973 people with T2D were included (mean age 53 years; mean baseline HbA1c 7.7%; obesity at diagnosis: 64%). During the first 5 years post-T2D diagnosis, 46-63% of the population did not have HbA1c < 6.5%, and > 60%, and > 80% of subjects did not achieve ≥ 5% and ≥ 10% weight loss, respectively. Early weight loss goal achievement (1st year after diagnosis) and weight loss magnitude were associated with a higher percentage of people with HbA1c < 6.5%.

CONCLUSIONS

Many individuals with T2D did not have HbA1c < 6.5% in the first 5 years after diagnosis and did not achieve ≥ 5% or ≥ 10% weight loss. Early weight loss after T2D diagnosis was associated with higher likelihood of achieving early glycaemic control.

摘要

引言

本研究的目的是确定2型糖尿病（T2D）诊断后的前5年内糖化血红蛋白（HbA1c）达标的人数以及实现减重目标的人数，并探讨西班牙常规护理中早期体重减轻与血糖控制之间的关系。

方法

这是一项使用IQVIA电子病历数据库的观察性回顾性研究，纳入年龄≤65岁新诊断为T2D的成年人。变量包括基线社会人口统计学/临床特征、每年的HbA1c和体重数据以及治疗模式。采用描述性统计和回归分析。

结果

共纳入8973例T2D患者（平均年龄53岁；平均基线HbA1c 7.7%；诊断时肥胖：64%）。在T2D诊断后的前5年中，46%-63%的人群HbA1c未<6.5%，分别有>60%和>80%的受试者未实现≥5%和≥10%的体重减轻。早期减重目标的实现（诊断后第1年）和减重幅度与HbA1c<6.5%的人群比例较高相关。