Shi Fachao, Yang Da, Sun Quanquan, Fang Caoyang
Department of Cardiology, Maanshan People's Hospital, Maanshan, Anhui, China.
Department of Emergency, First Affiliated Hospital of University of Science and Technology of China, Anhui Provincial Hospital, Hefei, Anhui, China.
PLoS One. 2025 May 19;20(5):e0323887. doi: 10.1371/journal.pone.0323887. eCollection 2025.
The purpose of this study was to investigate the relationship between the Dietary Index for Gut Microbiota (DI-GM) and hyperlipidemia (HL). The DI-GM, a novel index for assessing gut microbiota diversity, has not yet been thoroughly examined in relation to HL.
This research involved a cohort of 13,529 individuals enrolled from the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2020. We applied restricted cubic spline (RCS) analysis and weighted multivariable logistic regression to assess the association between DI-GM and HL, supplemented by subgroup analyses to reinforce these findings.
After multivariable adjustment, subjects with high intake of DI-GM were determined to have a significant reduced risk for developing HL, with a 5% reduced risk for HL for each one standard deviation increased in DI-GM (P = 0.01). In contrast with the group with a DI-GM < 3, HL in the group with a DI-GM > 6 was 40% reduced (P < 0.001). RCS analysis showed a negative linear dose-response relation between DI-GM and development of HL. Subgroup analysis showed an interaction between age-stratification and DI-GM (P = 0.01), but not with gender, racial, BMI, diabetes, and hypertension groups (P > 0.05).
Our study results show a significant negative linear correlation between DI-GM and HL. However, further research is needed to confirm our findings.
本研究旨在探讨肠道微生物群饮食指数（DI-GM）与高脂血症（HL）之间的关系。DI-GM是一种评估肠道微生物群多样性的新指标，尚未针对HL进行全面研究。
本研究纳入了2007年至2020年期间从美国国家健康与营养检查调查（NHANES）招募的13529名个体。我们应用受限立方样条（RCS）分析和加权多变量逻辑回归来评估DI-GM与HL之间的关联，并辅以亚组分析以强化这些结果。
经过多变量调整后，确定DI-GM高摄入量的受试者患HL的风险显著降低，DI-GM每增加一个标准差，HL风险降低5%（P = 0.01）。与DI-GM < 3的组相比，DI-GM > 6的组中HL降低了40%（P < 0.001）。RCS分析显示DI-GM与HL发生之间存在负线性剂量反应关系。亚组分析显示年龄分层与DI-GM之间存在交互作用（P = 0.01），但与性别、种族、BMI、糖尿病和高血压组之间不存在交互作用（P > 0.05）。
我们的研究结果显示DI-GM与HL之间存在显著的负线性相关性。然而，需要进一步的研究来证实我们的发现。
