肠道微生物群饮食指数与心血管疾病风险的关联：来自2007 - 2018年美国国家健康与营养检查调查（NHANES）的新证据

Association of dietary index of gut microbiota with cardiovascular disease risk: new evidence from NHANES 2007-2018.

作者信息

Jin Jiameng, Sun Xingang, Wang Lihong

机构信息

Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, 310053, China.

Department of Cardiology Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, 158 Shangtang Road, Hangzhou, Zhejiang Province, China.

出版信息

BMC Cardiovasc Disord. 2025 Apr 28;25(1):332. doi: 10.1186/s12872-025-04776-8.

DOI:10.1186/s12872-025-04776-8

PMID:40295908

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12039086/

Abstract

BACKGROUND

The dietary index of gut microbiota (DI-GM) is a newly proposed index for assessing dietary quality, and studies on its association with cardiovascular disease (CVD) are limited. This study aimed to investigate the association between DI-GM and the prevalence of CVD.

METHODS

We utilized data from the National Health and Nutrition Examination Survey (NHANES). Logistic regression analyses were performed to examine the association between DI-GM and CVD. Smoothed curve fitting was employed to explore potential nonlinear relationships. Additionally, subgroup analyses were conducted to assess the stability of the results.

RESULTS

The study included 22,590 participants, of whom 20,216 had no CVD and 2,374 had CVD. After adjusting for all covariates, the DI-GM score was significantly negatively associated with CVD risk, with a 4% reduction in CVD risk for each unit increase in DI-GM score (OR = 0.96, 95% CI: 0.94-0.99, P = 0.015). Notably, the highest DI-GM score group (6-12) had a 13% lower risk of CVD compared to the lowest DI-GM score group (0-3) (OR = 0.87, 95% CI: 0.76-1.00, P = 0.048).

CONCLUSION

The research results indicate that a higher DI-GM score protects against CVD, providing crucial empirical support for dietary intervention strategies based on gut microbiota modulation.

CLINICAL TRIAL NUMBER

Not applicable.

摘要

背景

肠道微生物群饮食指数（DI-GM）是一种新提出的评估饮食质量的指标，关于其与心血管疾病（CVD）关联的研究有限。本研究旨在探讨DI-GM与CVD患病率之间的关联。

方法

我们利用了美国国家健康与营养检查调查（NHANES）的数据。进行逻辑回归分析以检验DI-GM与CVD之间的关联。采用平滑曲线拟合来探索潜在的非线性关系。此外，进行亚组分析以评估结果的稳定性。

结果

该研究纳入了22,590名参与者，其中20,216人无CVD，2,374人患有CVD。在对所有协变量进行调整后，DI-GM得分与CVD风险显著负相关，DI-GM得分每增加一个单位，CVD风险降低4%（OR = 0.96，95%CI：0.94 - 0.99，P = 0.015）。值得注意的是，DI-GM得分最高组（6 - 12）的CVD风险比最低组（0 - 3）低13%（OR = 0.87，95%CI：0.76 - 1.00，P = 0.048）。