Aberg G, Adler G, Duker G, Ek B, Telemo E
Acta Pharmacol Toxicol (Copenh). 1979 Aug;45(2):102-6. doi: 10.1111/j.1600-0773.1979.tb02368.x.
The antiarrhythmic effects of dl'propranolol, d-propranolol, metoprolol and lidocaine against ouabain-induced cardiac arrhythmias were studied. It was found that contrary to earlier findings in the dog, the effects of the adrenergic beta-blockers against ouabain-arrhythmias in guinea pigs were due to beta-blocking activity and not the membrane-stabilizing activity of the compounds. The cardioselective beta-blocker, metoprolol, was more or equally effective as dl-propranolol against ouabain-induced arrhythmias in guinea pigs.
研究了dl-普萘洛尔、d-普萘洛尔、美托洛尔和利多卡因对哇巴因诱导的心律失常的抗心律失常作用。结果发现，与早期在犬身上的发现相反，肾上腺素能β受体阻滞剂对豚鼠哇巴因诱导的心律失常的作用是由于β受体阻滞活性，而非化合物的膜稳定活性。心脏选择性β受体阻滞剂美托洛尔在豚鼠中对哇巴因诱导的心律失常的作用与dl-普萘洛尔相当或更有效。
