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β受体阻滞剂与哇巴因诱导的心律失常的相关性。

The relevance of beta-receptor blockade to ouabain-induced cardiac arrhythmias.

作者信息

Dohadwalla A N, Freedberg A S, Vaughan Williams E M

出版信息

Br J Pharmacol. 1969 Jun;36(2):257-67. doi: 10.1111/j.1476-5381.1969.tb09503.x.

DOI:10.1111/j.1476-5381.1969.tb09503.x
PMID:5787666
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1703374/
Abstract
  1. (+)-propranolol and (+/-)-propranolol are comparable in their potency as a local anaesthetic on the intact and desheathed frog sciatic nerve.2. (+/-)-propranolol is much more potent than (+)-propranolol as a beta-receptor blocking agent and also more effective than the latter in protecting guinea-pigs against ouabain-induced ventricular fibrillation.3. In isolated rabbit atria (-)-, (+)- and (+/-)-propranolol, and I.C.I. 50172, which has hardly any local anaesthetic activity, greatly reduce the rate of rise of the intracellularly recorded action potential at concentrations which have no significant effect on electrical threshold, contractions, spontaneous frequency, maximum driving frequency, repolarization time or conduction velocity.
摘要

  1. （+）-普萘洛尔和（±）-普萘洛尔在对完整和去鞘青蛙坐骨神经的局部麻醉效力方面相当。

  2. （±）-普萘洛尔作为β受体阻滞剂的效力比（+）-普萘洛尔强得多，并且在保护豚鼠免受哇巴因诱导的心室颤动方面也比后者更有效。

  3. 在离体兔心房中，（-）-、（+）-和（±）-普萘洛尔以及几乎没有局部麻醉活性的ICI 50172，在对电阈值、收缩、自发频率、最大驱动频率、复极化时间或传导速度无显著影响的浓度下，能大大降低细胞内记录的动作电位的上升速率。

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