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健康的生活方式、日间嗜睡和肠道微生物群组成是人类功能力量的决定因素：一项横断面研究。

Healthy lifestyle, daytime sleepiness, and gut microbiome composition are determinants of functional strength in humans: a cross-sectional study.

作者信息

Norkeweit Friederike, Schlicht Kristina, Rohmann Nathalie, Hartmann Katharina, Türk Kathrin, Settgast Ute, Schulte Dominik M, Gilbert Felix, Demetrowitsch Tobias, Brix Fynn, Bang Corinna, Franke Andre, Schwarz Karin, Laudes Matthias, Geisler Corinna

机构信息

Institute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein and Kiel University, 24105, Kiel, Germany.

Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Campus Kiel, 24105, Kiel, Germany.

出版信息

Sci Rep. 2025 May 19;15(1):17378. doi: 10.1038/s41598-025-02519-5.

DOI:10.1038/s41598-025-02519-5
PMID:40389580
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12089321/
Abstract

Age, metabolic inflammation, sleep patterns, lifestyle choices, and gut microbiome composition were investigated as factors influencing functional strength. The Northern German FoCus cohort subgroup (394 women, 233 men) was categorized into six groups based on weekly sports activity and handgrip strength (HGS) measurements. The analyses included anthropometric data, clinical biochemistry, medication, sleep duration, healthy lifestyle score (HLS), 16 S rRNA gut microbiota, serum and urine metabolomics, bile acids, and an adapted dietary inflammatory index (ADII) score. Associations were found between age, inflammation, and low functional strength, with sleep duration increasing the odds and a healthy lifestyle decreasing the risk. Urine metabolomics revealed differences in enrichment analyses. No significant differences were observed in the Chao1 and InVSimpson indices between the groups. At the genus level, some species were associated with daily sports activity, whereas others were associated with HGS measurements. Clostridium XIVa was found only in high- and medium-HGS groups, while Alistipes, Odoribacter, and Streptococcus decreased with activity. Thus, tailored lifestyle interventions may reduce the risk of poor functional strength.

摘要

研究了年龄、代谢性炎症、睡眠模式、生活方式选择和肠道微生物群组成作为影响功能强度的因素。根据每周体育活动和握力（HGS）测量结果，将北德FoCus队列亚组（394名女性，233名男性）分为六组。分析包括人体测量数据、临床生物化学、药物治疗、睡眠时间、健康生活方式评分（HLS）、16S rRNA肠道微生物群、血清和尿液代谢组学、胆汁酸以及调整后的饮食炎症指数（ADII）评分。发现年龄、炎症与低功能强度之间存在关联，睡眠时间增加了几率，健康的生活方式降低了风险。尿液代谢组学揭示了富集分析中的差异。各组之间在Chao1和InVSimpson指数上未观察到显著差异。在属水平上，一些物种与日常体育活动相关，而其他物种与HGS测量相关。仅在高HGS和中HGS组中发现了梭状芽孢杆菌XIVa，而阿利斯杆菌属、气味杆菌属和链球菌属随着活动量的增加而减少。因此，量身定制的生活方式干预措施可能会降低功能强度不佳的风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866c/12089321/978810e0c3f4/41598_2025_2519_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866c/12089321/c8e773a747b3/41598_2025_2519_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866c/12089321/ca32eb0f5b91/41598_2025_2519_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866c/12089321/193ca0fdc282/41598_2025_2519_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866c/12089321/978810e0c3f4/41598_2025_2519_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866c/12089321/c8e773a747b3/41598_2025_2519_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866c/12089321/ca32eb0f5b91/41598_2025_2519_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866c/12089321/193ca0fdc282/41598_2025_2519_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866c/12089321/978810e0c3f4/41598_2025_2519_Fig4_HTML.jpg

相似文献

[1]
Healthy lifestyle, daytime sleepiness, and gut microbiome composition are determinants of functional strength in humans: a cross-sectional study.

Sci Rep. 2025-5-19

[2]
Physical activity and fiber intake beneficial for muscle mass and strength preservation during aging: A comprehensive cross-sectional study in the UK biobank cohort.

Exp Gerontol. 2024-8

[3]
Gut microbiome diversity is associated with muscle mass, strength and quality in post-stroke patients.

Clin Nutr ESPEN. 2025-6

[4]
Serum metabolome and gut microbiome alterations are associated with low handgrip strength in older adults.

Aging (Albany NY). 2024-2-1

[5]
Associations between Diet, the Gut Microbiome, and Short-Chain Fatty Acid Production among Older Caribbean Latino Adults.

J Acad Nutr Diet. 2020-12

[6]
Metabolic and lifestyle factors accelerate disease onset and alter gut microbiome in inflammatory non-communicable diseases.

BMC Med. 2024-10-24

[7]
Gut microbiome composition changes in obstructive sleep apnoea syndrome also in relation to excessive daytime sleepiness.

Brain Res Bull. 2025-3

[8]
Handgrip strength and muscle quality in Australian women: cross-sectional data from the Geelong Osteoporosis Study.

J Cachexia Sarcopenia Muscle. 2020-6

[9]
Sarcopenia-related features and factors associated with low muscle mass, weak muscle strength, and reduced function in Chinese rural residents: a cross-sectional study.

Arch Osteoporos. 2018-12-17

[10]
Factors associated with handgrip strength across the life course: A systematic review.

J Cachexia Sarcopenia Muscle. 2024-12

本文引用的文献

[1]
The associations of butyrate-producing bacteria of the gut microbiome with diet quality and muscle health.

Gut Microbiome (Camb). 2021-8-13

[2]
Microbiota independent effects of oligosaccharides on Caco-2 cells -A semi-targeted metabolomics approach using DI-FT-ICR-MS coupled with pathway enrichment analysis.

Front Mol Biosci. 2022-10-24

[3]
Cohort profile: the Food Chain Plus (FoCus) cohort.

Eur J Epidemiol. 2022-10

[4]
Sex-specific associations between gut microbiota and skeletal muscle mass in a population-based study.

J Cachexia Sarcopenia Muscle. 2022-12

[5]
Sustained Endurance Training Leads to Metabolomic Adaptation.

Metabolites. 2022-7-16

[6]
Population-based metagenomics analysis reveals altered gut microbiome in sarcopenia: data from the Xiangya Sarcopenia Study.

J Cachexia Sarcopenia Muscle. 2022-10

[7]
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BMC Med. 2022-6-2

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A metabolic axis in obesity and type 2 diabetes.

Gut Microbes. 2022

[9]
Ranking the biases: The choice of OTUs vs. ASVs in 16S rRNA amplicon data analysis has stronger effects on diversity measures than rarefaction and OTU identity threshold.

PLoS One. 2022

[10]
Sarcopenia Is a Cause and Consequence of Metabolic Dysregulation in Aging Humans: Effects of Gut Dysbiosis, Glucose Dysregulation, Diet and Lifestyle.

Cells. 2022-1-20

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