Wang Mina, Ren Yashuo, Xiao Hongli, Liu Anming, Ma Chunying, Li Zhuohao, Wang Zixi, Xia Qiuyu, Dou Pu, Li Bin, Chen Peng
Graduate School, Beijing University of Chinese Medicine, Beijing, 100029, People's Republic of China.
Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100010, People's Republic of China.
J Pain Res. 2024 Sep 18;17:3021-3030. doi: 10.2147/JPR.S485481. eCollection 2024.
Parkinson's disease (PD)-related chronic pain is a prevalent non-motor symptom, this study aimed to detect the effect and safety of fire needling therapy (FNT) for PD-related chronic pain relief.
Patients with PD-related chronic pain were randomly allocated to FNT group and control group with a treatment phase of 8 weeks and a follow-up phase of 4 weeks. Primary outcome was the King's Parkinson's Pain Scale (KPPS), Secondary outcomes included Visual Analogue Scale (VAS), Unified Parkinson's Disease Rating Scale-III (UPDRS-III), and the Parkinson's Disease Questionnaire-39 (PDQ-39). Study was registered on Chinese Clinical Trial Registry (Registered number: ChiCTR2400084951).
60 participants were randomized, with 30 in the FNT group and 30 in the control group. KPPS was significantly influenced by the interaction of treatment and time, with a significant reduction in pain observed in the FNT group compared to the control group at Week 4 (difference [95% CI]: -20.693[-27.619,-13.767], P<0.001), Week 8 (difference [95% CI]: 44.680[-52.359,-37.000], P<0.001), and Week 12 (difference [95% CI]: -44.982[-52.771,-37.193], P<0.001). For VAS, UPDRS-III, and PDQ-39, there were significant differences between groups at Week 4, Week 8, and Week 12.
FNT could be an effective and safe method for managing PD-related chronic pain. However, large-sample studies conducted in multiple centers are necessary to further verify the findings in the future.
帕金森病（PD）相关的慢性疼痛是一种常见的非运动症状，本研究旨在检测火针疗法（FNT）缓解PD相关慢性疼痛的疗效和安全性。
将PD相关慢性疼痛患者随机分为FNT组和对照组，治疗期为8周，随访期为4周。主要结局指标为国王帕金森疼痛量表（KPPS），次要结局指标包括视觉模拟量表（VAS）、统一帕金森病评定量表第三部分（UPDRS-III）和帕金森病问卷-39（PDQ-39）。该研究已在中国临床试验注册中心注册（注册号：ChiCTR2400084951）。
60名参与者被随机分组，FNT组30名，对照组30名。KPPS受到治疗与时间交互作用的显著影响，与对照组相比，FNT组在第4周（差值[95%CI]：-20.693[-27.619，-13.767]，P<0.001）、第8周（差值[95%CI]：44.680[-52.359，-37.000]，P<0.001）和第12周（差值[95%CI]：-44.982[-52.771，-37.193]，P<0.001）时疼痛显著减轻。对于VAS、UPDRS-III和PDQ-39，在第4周、第8周和第12周时两组之间存在显著差异。
火针疗法可能是一种有效且安全的管理PD相关慢性疼痛的方法。然而，未来有必要进行多中心大样本研究以进一步验证这些结果。
