Guan Mengtong, Zhang Xinyu, Li Xinhe, Liao Bo, Han Wang, Tan Jindong, Wang Zijie, Wang Lichen, Shen Jieliang, Han Xiaoyu, Bai Dingqun
Department of Rehabilitation Medicine Key Laboratory of Physical Medicine and Precision Rehabilitation of Chongqing Municipal Health Commission The First Affiliated Hospital of Chongqing Medical University Chongqing China.
State Key Laboratory of Ultrasound in Medicine and Engineering Chongqing Medical University Chongqing China.
Smart Med. 2025 May 16;4(2):e70003. doi: 10.1002/smmd.70003. eCollection 2025 Jun.
With the intensification of global population aging, osteoarthritis (OA) has emerged as a major socioeconomic burden requiring urgent therapeutic interventions. Low-intensity pulsed ultrasound (LIPUS), a non-invasive physical therapy modality, delivers pulsed acoustic energy to target tissues with negligible thermal effects. Accumulating evidence from preclinical studies and randomized controlled trials has demonstrated its potential to decelerate OA progression. This systematic review synthesizes current knowledge on LIPUS-mediated OA management, elucidates mechanistic pathways through biomechanical and molecular analyses, strategies combining LIPUS with biomaterials to improve its efficacy, evaluates clinical translation challenges, and proposes standardized treatment protocols to optimize therapeutic outcomes.
随着全球人口老龄化的加剧，骨关节炎（OA）已成为一项重大的社会经济负担，亟需进行治疗干预。低强度脉冲超声（LIPUS）作为一种非侵入性物理治疗方式，能将脉冲声能传递至目标组织，产生的热效应可忽略不计。临床前研究和随机对照试验积累的证据表明，其具有减缓骨关节炎进展的潜力。本系统综述综合了目前关于LIPUS介导的骨关节炎治疗的知识，通过生物力学和分子分析阐明其作用机制，探讨将LIPUS与生物材料相结合以提高疗效的策略，评估临床转化面临的挑战，并提出标准化治疗方案以优化治疗效果。
