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低强度脉冲超声对膝骨关节炎髌下脂肪垫的影响:一项随机、双盲、安慰剂对照试验

Effects of low-intensity pulsed ultrasound on the infrapatellar fat pad in knee osteoarthritis: a randomized, double blind, placebo-controlled trial.

作者信息

Kitano Masashi, Kawahata Hirohisa, Okawa Yuse, Handa Toyokazu, Nagamori Hiroki, Kitayama Yoshiki, Miyashita Toshinori, Sakamoto Kodai, Fukumoto Yusuke, Kudo Shintarou

机构信息

Graduate School of Health Science, Morinomiya University of Medical Science: 1-26-16 Nankoukita, Suminoe-ku, Osaka-shi, Osaka 559-8611, Japan.

Inclusive Medical Science Research Institute, Morinomiya University of Medical Sciences, Japan.

出版信息

J Phys Ther Sci. 2023 Mar;35(3):163-169. doi: 10.1589/jpts.35.163. Epub 2023 Mar 1.

DOI:10.1589/jpts.35.163
PMID:36866007
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9974316/
Abstract

[Purpose] We investigated the effects of low-intensity pulsed ultrasound (LIPUS) irradiation of the infrapatellar fat pad (IFP) combined with therapeutic exercise for management of knee osteoarthritis (knee OA). [Participants and Methods] The study included 26 patients with knee OA, who were randomized into the LIPUS group (patients underwent LIPUS + therapeutic exercise) and the therapeutic exercise group (patients underwent sham LIPUS + therapeutic exercise). We measured changes in the patellar tendon-tibial angle (PTTA) and in IFP thickness, IFP gliding, and IFP echo intensity after 10 treatment sessions to determine the effects of the aforementioned interventions. We additionally recorded changes in the visual analog scale, Timed Up and Go Test, the Western Ontario and McMaster Universities Osteoarthritis Index, and Kujala scores, as well as range of motion in each group at the same end-point. [Results] Compared with patients in the therapeutic exercise group, those in the LIPUS group showed significant post-treatment improvements in PTTA, VAS, and Kujala scores, as well as in range of motion. [Conclusion] The combined use of LIPUS irradiation of the IFP and therapeutic exercise is a safe and effective modality to reduce IFP swelling, relieve pain, and improve function in patients with knee OA.

摘要

[目的] 我们研究了低强度脉冲超声(LIPUS)照射髌下脂肪垫(IFP)联合治疗性运动对膝关节骨关节炎(膝骨关节炎)的治疗效果。[参与者与方法] 该研究纳入了26例膝骨关节炎患者,他们被随机分为LIPUS组(患者接受LIPUS + 治疗性运动)和治疗性运动组(患者接受假LIPUS + 治疗性运动)。在10次治疗疗程后,我们测量了髌腱 - 胫骨角(PTTA)、IFP厚度、IFP滑动度和IFP回声强度的变化,以确定上述干预措施的效果。我们还记录了视觉模拟量表、计时起立行走测试、西安大略和麦克马斯特大学骨关节炎指数以及库贾拉评分的变化,以及每组在同一终点的关节活动范围。[结果] 与治疗性运动组患者相比,LIPUS组患者在治疗后PTTA、VAS和库贾拉评分以及关节活动范围方面均有显著改善。[结论] LIPUS照射IFP与治疗性运动联合使用是一种安全有效的方法,可减轻膝骨关节炎患者的IFP肿胀、缓解疼痛并改善功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/380e/9974316/d1c8e6ada11f/jpts-35-163-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/380e/9974316/89ceab98fe98/jpts-35-163-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/380e/9974316/c2724b85ddc3/jpts-35-163-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/380e/9974316/d1c8e6ada11f/jpts-35-163-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/380e/9974316/89ceab98fe98/jpts-35-163-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/380e/9974316/c2724b85ddc3/jpts-35-163-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/380e/9974316/d1c8e6ada11f/jpts-35-163-g003.jpg

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本文引用的文献

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Biomed Rep. 2022 Aug 9;17(4):79. doi: 10.3892/br.2022.1562. eCollection 2022 Oct.
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Hyperechoic and Low Morphological Changes in the Prefemoral Fat Pad in Individuals with Knee Osteoarthritis Based on Ultrasonographic Findings.基于超声检查结果的膝骨关节炎患者股前脂肪垫的高回声及形态学低改变
J Med Ultrasound. 2021 Jan 22;29(2):105-110. doi: 10.4103/JMU.JMU_85_20. eCollection 2021 Apr-Jun.
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肥胖和脂肪组织功能障碍在骨关节炎疼痛中的作用。
Nat Rev Rheumatol. 2024 Sep;20(9):565-584. doi: 10.1038/s41584-024-01143-3. Epub 2024 Aug 7.
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Effect of Low-Intensity Pulsed Ultrasound on Macrophage Properties and Fibrosis in the Infrapatellar Fat Pad in a Carrageenan-Induced Knee Osteoarthritis Rat Model.低强度脉冲超声对角叉菜胶诱导的膝骨关节炎大鼠模型髌下脂肪垫巨噬细胞特性及纤维化的影响
Cureus. 2024 Apr 29;16(4):e59246. doi: 10.7759/cureus.59246. eCollection 2024 Apr.
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Effects of therapeutic ultrasound in patients with knee osteoarthritis: A systematic review and meta-analysis.治疗性超声对膝骨关节炎患者的影响:一项系统评价和荟萃分析。
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OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis.
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Biomechanical behavior of Hoffa's fat pad in healthy and osteoarthritic conditions: histological and mechanical investigations.健康和骨关节炎状态下 Hoffa 脂肪垫的生物力学行为:组织学和力学研究
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Soft tissue micro-circulation in the healthy hindfoot: a cross-sectional study with focus on lateral surgical approaches to the calcaneus.健康后足的软组织微循环:一项聚焦于跟骨外侧手术入路的横断面研究。
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Knee Surg Sports Traumatol Arthrosc. 2018 Nov;26(11):3515-3524. doi: 10.1007/s00167-018-4943-1. Epub 2018 Apr 20.