Ponniah Subramanian Arul Rajamurugan, Chithrabhanu Anoop, Venugopal Rohit, Narayanswamy Sudha, Periaswamy Vairamala
Madras Medical College, No 3 EVR Periyar Salai, Chennai, Tamilnadu, 600003 India.
J Obstet Gynaecol India. 2025 Apr;75(Suppl 1):585-588. doi: 10.1007/s13224-024-02077-2. Epub 2024 Dec 12.
Endometriosis is a prevalent gynecological disorder that often leads to infertility and presents a complex challenge in its diagnosis and management. This report describes a case history of a 38-year-old woman suffering from rheumatoid arthritis and primary infertility who became pregnant after the initiation of tofacitinib treatment for rheumatoid arthritis. Her disease activity was well-controlled, and she became pregnant six months after the initiation of tofacitinib. We could not find any earlier reports of pregnancy in humans following tofacitinib treatment for endometriosis-related infertility in the literature. This observation suggests a potential link between the JAK pathway, inflammation associated with endometriosis and fertility. Although promising, cautious exploration of the possibility with large controlled studies are essential to validate these findings and assess the safety and efficacy of JAK inhibitors in endometriosis treatment.
子宫内膜异位症是一种常见的妇科疾病，常导致不孕，其诊断和治疗面临复杂挑战。本报告描述了一名38岁患有类风湿性关节炎和原发性不孕的女性病例，该女性在开始使用托法替布治疗类风湿性关节炎后怀孕。她的疾病活动得到了良好控制，在开始使用托法替布六个月后怀孕。我们在文献中未找到任何关于托法替布治疗子宫内膜异位症相关不孕后人类怀孕的早期报告。这一观察结果提示了JAK通路、与子宫内膜异位症相关的炎症和生育能力之间的潜在联系。尽管前景乐观，但通过大型对照研究谨慎探索这种可能性对于验证这些发现以及评估JAK抑制剂在子宫内膜异位症治疗中的安全性和有效性至关重要。
