Samy K Sushma, Asnani Mona, Agarwal Anjoo, Singh Renu, Ali Wahid
Department of Obstetrics and Gynaecology, Rani Durgavati Medical College, Banda, India.
Department of Obstetrics and Gynaecology, KGMU, Lucknow, India.
J Obstet Gynaecol India. 2025 Apr;75(Suppl 1):487-493. doi: 10.1007/s13224-024-02093-2. Epub 2025 Jan 17.
Placenta accreta spectrum (PAS) disorders and placenta praevia (PP) are major life-threatening obstetric complications. Pro-brain natriuretic peptide (ProBNP) and troponin I are circulatory biomarkers related to increased angiogenesis and tissue destruction.
The aim was to evaluate the ProBNP and troponin I levels in placenta praevia and PAS and compare their levels between cases and their corresponding matched controls in terms of age, gestational age, and BMI.
A case-control study was conducted over one year; ProBNP and troponin I levels were evaluated and compared in a total of 120 women enrolled, in which 30 women were of placenta praevia, 30 women were of PAS, and 60 controls (30 each) matched to corresponding controls in terms of age, gestational age, and BMI. In all recruited women, biomarker levels were detected by immunofluorescence assay method. All cases and controls were evaluated and compared in terms of demographic profile, risk factors, and maternal and perinatal outcomes.
In placenta praevia patients, lower mean ProBNP (0.42) and higher troponin I levels (1.58) were observed as compared to their matched controls, but this difference was not significant statistically. PAS patients had statistically significant higher mean ProBNP (1.24) as well as troponin I levels (3.84) as compared to their matched controls ( < 0.001) (z = 4.356).
Both ProBNP and troponin I levels were found to be higher in cases of PAS. Troponin I had an edge over ProBNP in the identification of PAS and adverse maternal and perinatal outcomes. Both may be used as diagnostic as well as prognostic markers in the future.
胎盘植入谱系疾病（PAS）和前置胎盘（PP）是严重威胁生命的产科并发症。脑钠肽原（ProBNP）和肌钙蛋白I是与血管生成增加和组织破坏相关的循环生物标志物。
评估前置胎盘和胎盘植入谱系疾病患者的ProBNP和肌钙蛋白I水平，并在年龄、孕周和体重指数方面将病例组与相应的匹配对照组进行水平比较。
进行了一项为期一年的病例对照研究；对总共120名入组女性的ProBNP和肌钙蛋白I水平进行了评估和比较，其中30名女性为前置胎盘患者，30名女性为胎盘植入谱系疾病患者，60名对照组（每组30名）在年龄、孕周和体重指数方面与相应病例匹配。在所有招募的女性中，通过免疫荧光测定法检测生物标志物水平。对所有病例和对照组在人口统计学特征、危险因素以及孕产妇和围产儿结局方面进行评估和比较。
与匹配对照组相比，前置胎盘患者的平均ProBNP水平较低（0.42），肌钙蛋白I水平较高（1.58），但这种差异在统计学上不显著。与匹配对照组相比，胎盘植入谱系疾病患者的平均ProBNP水平（1.24）以及肌钙蛋白I水平（3.84）在统计学上显著更高（<0.001）（z = 4.356）。
发现胎盘植入谱系疾病患者的ProBNP和肌钙蛋白I水平均较高。在识别胎盘植入谱系疾病以及不良孕产妇和围产儿结局方面，肌钙蛋白I比ProBNP更具优势。两者未来均可作为诊断和预后标志物。
