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三尖瓣腱索组织的粘弹性建模

Viscoelastic modelling of the tricuspid valve chordae tendineae tissue.

作者信息

Liu Li-Wei, Lee Chung-Hao, Aggarwal Ankush, Chao Chih-Ming, Ross Colton J, Liao Yu-Kai

机构信息

Department of Engineering Science, National Cheng Kung University, Tainan 70101, Taiwan.

School of Aerospace and Mechanical Engineering, The University of Oklahoma, Norman, OK 73019, USA.

出版信息

Appl Math Model. 2022 May;105:648-669. doi: 10.1016/j.apm.2021.12.028. Epub 2022 Jan 13.

Abstract

In the present study, the mechanical behavior of tricuspid valve (TV) chordae tendineae tissue is investigated experimentally and theoretically. A series of uniaxial mechanical testing experiments of the TV chordae tendineae is conducted and its viscoelastic model is developed by taking into account the initial condition of displacement of the tissue. Our experimental result shows the typical J-shaped force-displacement curve of the TV chordae tendineae and the corresponding viscoelastic model is established via a nonlinear spring is installed to replace the linear spring of the generalized Kelvin model. In addition, specified arrangements of the model parameters and the initial condition of the individual Kelvin element are proposed. The exact solutions of the model under step-wise and constant-rate forces are analytically derived and calibration of the model constants is addressed. The resulted simulation is compared with uniaxial mechanical testing of the TV chordae tendineae tissue and shows superior performance of the proposed model under creep and monotonic loading experiments. Furthermore, the sensitivity analysis and the parameter study of the model parameters are performed to examine the influence of initial conditions of displacement as well as other internal variables on the model response under step-wise and constant-rate forces.

摘要

在本研究中,对三尖瓣腱索组织的力学行为进行了实验和理论研究。进行了一系列三尖瓣腱索的单轴力学测试实验,并通过考虑组织位移的初始条件建立了其粘弹性模型。我们的实验结果显示了三尖瓣腱索典型的J形力-位移曲线,并通过安装非线性弹簧来替代广义开尔文模型的线性弹簧建立了相应的粘弹性模型。此外,还提出了模型参数的特定排列以及各个开尔文元件的初始条件。解析推导了模型在阶跃力和恒速力作用下的精确解,并讨论了模型常数的校准。将所得模拟结果与三尖瓣腱索组织的单轴力学测试进行比较,结果表明所提出的模型在蠕变和单调加载实验中具有优越的性能。此外,还进行了模型参数的敏感性分析和参数研究,以考察位移初始条件以及其他内部变量在阶跃力和恒速力作用下对模型响应的影响。

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