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肝硬化伴不安腿综合征的经皮电神经刺激：一项初步研究。

Transcutaneous electric nerve stimulation in restless leg syndrome with cirrhosis: a pilot study.

作者信息

Batra Swansu, Paliwal Vimal Kumar, Goel Amit, Gupta Ankit, Kishore Ravi V Krishna, Mishra Ajay Kumar, Garg Sachin, Mishra Prabhakar, Kapoor Vishwas

机构信息

Department of Neurology, SGPGIMS, Lucknow, India.

Department of Hepatology, SGPGIMS, Lucknow, India.

出版信息

Expert Rev Med Devices. 2025 May 20. doi: 10.1080/17434440.2025.2508872.

DOI:10.1080/17434440.2025.2508872

PMID:40391712

Abstract

BACKGROUND

The study aimed to evaluate the effect of transcutaneous electric nerve stimulation (TENS) on restless leg syndrome (RLS) severity, sleep, quality of life, anxiety, and depression in liver cirrhosis patients.

RESEARCH DESIGN AND METHODS

This was single-arm, open label, pilot study. Cirrhosis patients with RLS were evaluated with International RLS Score (IRLSS, scored 0-40 for severity) at baseline and 1, 2, 4, 6 weeks. Sleep quality, quality of life, depression and anxiety was assessed using Pittsburg Sleep Quality Index (PSQI, 0-21 with poor sleep), RLS Quality of Life Questionnaire (RLSQoL, 18 items, 13 scored 0-15, higher score - good quality of life), Hamilton Depression Rating Scale (HAM-D, scored 0-53 with increasing depression) and Hamilton Anxiety Rating Scale (HAM-A, scored 0 to 56 with increasing anxiety) at baseline and 4 weeks of TENS.

RESULTS

Twenty-five patients (mean age 52 ± 9.1 years, 52% females) received TENS. Mean IRLSS improved from 22.28 ± 6.724 to 6.08 ± 5.590, 7.48 ± 7.206, 8.56 ± 6.715, 11.76 ± 5.456 after 1, 2, 4 and 6 weeks. Baseline Sleep quality, quality of life, anxiety and depression scores (9.6 ± 5.1, 73 ± 20.7, 25.4 ± 11.7, 19.2 ± 10.6) improved after 4 weeks of TENS (4.7 ± 3, 94.9 ± 12.5, 8.9 ± 5.7,7.5 ± 5).

CONCLUSION

Transcutaneous Electric Nerve Stimulation improved RLS symptoms, sleep quality, anxiety, depression, and overall quality of life in cirrhosis patients.

TRIAL REGISTRATION

Clinical Trial Registry of India - CTRI/2023/06/053734.

摘要

背景

本研究旨在评估经皮电神经刺激（TENS）对肝硬化患者不安腿综合征（RLS）严重程度、睡眠、生活质量、焦虑和抑郁的影响。

研究设计与方法

这是一项单臂、开放标签的试点研究。对患有RLS的肝硬化患者在基线时以及1、2、4、6周时采用国际RLS评分（IRLSS，严重程度评分为0 - 40分）进行评估。在基线时以及TENS治疗4周后，使用匹兹堡睡眠质量指数（PSQI，0 - 21分，分数越低睡眠质量越差）、RLS生活质量问卷（RLSQoL，18项，其中13项评分为0 - 15分，分数越高生活质量越好）、汉密尔顿抑郁评定量表（HAM - D，0 - 53分，分数越高抑郁程度越高）和汉密尔顿焦虑评定量表（HAM - A，0 - 56分，分数越高焦虑程度越高）评估睡眠质量、生活质量、抑郁和焦虑情况。

结果

25名患者（平均年龄52 ± 9.1岁，52%为女性）接受了TENS治疗。平均IRLSS在1、2、4和6周后分别从22.28 ± 6.724改善至6.08 ± 5.590、7.48 ± 7.206、8.56 ± 6.715、11.76 ± 5.456。基线时的睡眠质量、生活质量、焦虑和抑郁评分（9.6 ± 5.1、73 ± 20.7、25.4 ± 11.7、19.2 ± 10.6）在TENS治疗4周后有所改善（4.7 ± 3、94.9 ± 12.5、8.9 ± 5.7、7.5 ± 5）。