Schröder Dominik, Stölting Andrea, Müllenmeister Christina, Behrens Georg M N, Klawitter Sandra, Klawonn Frank, Cook Aisha, Wegner Nadja, Wetzke Martin, Schmachtenberg Tim, Dopfer-Jablonka Alexandra, Müller Frank, Happle Christine
Department of General Practice, University Medical Center Göttingen, Göttingen, Germany.
Department of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany.
PLoS One. 2025 May 20;20(5):e0312714. doi: 10.1371/journal.pone.0312714. eCollection 2025.
Post-COVID syndrome (PCS) poses enormous clinical challenges. Occupational therapy (OT) is recommended in PCS, but structural validation of this concept is pending.
In an unblinded randomized pilot study (clinical trial # DRKS0026007), feasibility and effects of online OT in PCS were tested. Probands received structured online OT over 12 weeks either via interactive online treatment sessions (interactive group) or prerecorded videos (video group). 50% of probands received no online OT (control group). At week 0, 12, and 24, we analyzed study experience, health-related quality of life, cognitive functions. impairment in performance, and social participation.
N = 158 probands (mean age 38 yrs., 86% female) were included into the analyses. The study experience was described as positive or very positive in 83.3% of probands in the interactive versus 48.1% of probands in the video group (p = 0.001). After 12 weeks, all groups displayed significant improvement in concentration, memory, and performance of daily tasks. After 24 weeks, significant improvement in concentration and memory were observed in control- and video-probands, and social participation had improved after video-OT. However, only probands in the interactive online OT group showed improvement of all measured endpoints including concentration, memory, quality of life, and social participation.
We show that online OT is feasible, and that interactive online OT is a promising treatment strategy for affected patients. We present exploratory data on its efficacy and describe variables that can be employed for further investigations in confirmatory trials.
新冠后综合征（PCS）带来了巨大的临床挑战。PCS 推荐采用职业疗法（OT），但这一概念的结构验证仍在进行中。
在一项非盲随机试点研究（临床试验编号#DRKS0026007）中，测试了在线 OT 对 PCS 的可行性和效果。研究对象在 12 周内通过交互式在线治疗课程（互动组）或预录制视频（视频组）接受结构化在线 OT。50%的研究对象未接受在线 OT（对照组）。在第 0、12 和 24 周，我们分析了研究体验、健康相关生活质量、认知功能、表现受损情况和社会参与度。
纳入分析的研究对象有 N = 158 名（平均年龄 38 岁，86%为女性）。互动组中 83.3%的研究对象将研究体验描述为积极或非常积极，而视频组中这一比例为 48.1%（p = 0.001）。12 周后，所有组在注意力、记忆力和日常任务表现方面均有显著改善。24 周后，对照组和视频组的研究对象在注意力和记忆力方面有显著改善，视频 OT 后社会参与度有所提高。然而，只有互动在线 OT 组的研究对象在所有测量终点上都有改善，包括注意力、记忆力、生活质量和社会参与度。
我们表明在线 OT 是可行的，且互动在线 OT 对受影响患者是一种有前景的治疗策略。我们展示了关于其疗效的探索性数据，并描述了可用于在确证性试验中进一步研究的变量。
