耳微电刺激：纳洛酮可逆性减轻阿片类戒断综合征

Auricular microelectrostimulation: naloxone-reversible attenuation of opiate abstinence syndrome.

作者信息

Malin D H, Murray J B, Crucian G P, Schweitzer F C, Cook R E, Skolnick M H

机构信息

Program in Behavioral Science, University of Houston-Clear Lake, TX 77058.

出版信息

Biol Psychiatry. 1988 Dec;24(8):886-90. doi: 10.1016/0006-3223(88)90223-5.

DOI:10.1016/0006-3223(88)90223-5

PMID:2852967

Abstract

This study evaluated the effects in rats of very low amplitude (10 mu amp) charge-balanced 10-Hz stimulation delivered bilaterally to low impedance points on the outer ear. This microelectrostimulation markedly and significantly reduced the number of opiate abstinence signs observed following a week of continuous morphine infusion. This effect was prevented by subcutaneous injection of 3 mg/kg naloxone, suggesting that stimulation of endogenous opioid activity plays a major role in the actions of auricular microelectrostimulation.

摘要

本研究评估了以极低幅度（10微安）、电荷平衡的10赫兹刺激双侧外耳低阻抗点对大鼠产生的影响。这种微电刺激显著减少了连续一周输注吗啡后观察到的阿片类戒断症状的数量。皮下注射3毫克/千克纳洛酮可阻止这种效应，这表明内源性阿片类活性的刺激在耳穴微电刺激的作用中起主要作用。