Yudhanto Setyo, Maddox Carol W, Varga Csaba, Hung Chien-Che
Department of Pathobiology, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA; Department of Veterinary Public Health, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Department of Pathobiology, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA; Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.
Res Vet Sci. 2025 Aug;192:105695. doi: 10.1016/j.rvsc.2025.105695. Epub 2025 May 15.
Information on antimicrobial resistance patterns of urinary pathogens of cats can aid veterinarians in their antimicrobial prescription choices. We assessed the prevalence and antimicrobial resistance of bacteria isolated from urine samples of cats with urinary tract infections (UTIs) submitted to a veterinary diagnostic laboratory in Illinois between 2020 and 2022. The laboratory received 2026 urine samples during the study period, of which 606 (29.97%) showed bacterial growth, and from these samples, 883 bacterial strains were recovered. The most common gram-positive bacterial species included Enterococcus faecalis (n = 123), Staphylococcus felis (n = 50), and Staphylococcus pseudintermedius (n = 28), while the most common gram-negative bacteria included Escherichia coli (n = 322) and Proteus mirabilis (n = 18). Among the gram-positive isolates, none of the Enterococcus faecalis isolates showed resistance to amoxicillin-clavulanic acid and ampicillin. In addition, Staphylococcus felis isolates showed low resistance to ampicillin (7.32%), enrofloxacin (4.88%), and amoxicillin-clavulanic acid (4.88%). Among gram-negative bacteria, E. coli isolates showed a high resistance to ampicillin (30.64%), and a moderate resistance to amoxicillin-clavulanic acid (11.78%) and cefovecin (11.11%), antibiotics considered as first-line choices to treat UTIs in cats. Compared to 2020, the rate of E. coli isolates resistant to amoxicillin-clavulanic acid was lower in 2022 (IRR: 0.42; 95%; CI: 0.18-0.99). This study provides antibiograms of common feline urinary pathogens in Illinois that could aid veterinarians in their empirical UTI therapy choices. Requesting an antimicrobial susceptibility test when starting an empirical treatment could be beneficial to guide altered therapy to secure treatment success if the causative pathogens are resistant to the empirical antimicrobial choices.
有关猫泌尿系统病原体的抗菌药物耐药模式的信息，有助于兽医选择抗菌药物处方。我们评估了2020年至2022年间提交给伊利诺伊州一家兽医诊断实验室的患有尿路感染（UTIs）的猫的尿液样本中分离出的细菌的流行情况和抗菌药物耐药性。在研究期间，该实验室收到了2026份尿液样本，其中606份（29.97%）显示有细菌生长，从这些样本中，共分离出883株细菌菌株。最常见的革兰氏阳性菌包括粪肠球菌（n = 123）、猫葡萄球菌（n = 50）和中间型葡萄球菌（n = 28），而最常见的革兰氏阴性菌包括大肠杆菌（n = 322）和奇异变形杆菌（n = 18）。在革兰氏阳性分离株中，没有一株粪肠球菌分离株对阿莫西林-克拉维酸和氨苄西林耐药。此外，猫葡萄球菌分离株对氨苄西林（7.32%）、恩诺沙星（4.88%）和阿莫西林-克拉维酸（4.88%）的耐药率较低。在革兰氏阴性菌中，大肠杆菌分离株对氨苄西林的耐药率较高（30.64%），对阿莫西林-克拉维酸（11.78%）和头孢维星（11.11%）的耐药率中等，这两种抗生素被认为是治疗猫尿路感染的一线选择。与2020年相比，2022年对阿莫西林-克拉维酸耐药的大肠杆菌分离株的比例较低（发病率比值比：0.42；95%；置信区间：0.18 - 0.99）。本研究提供了伊利诺伊州常见猫泌尿系统病原体的抗菌谱，这有助于兽医在经验性治疗尿路感染时做出选择。在开始经验性治疗时进行抗菌药物敏感性试验，如果致病病原体对经验性抗菌药物选择耐药，可能有助于指导调整治疗方案以确保治疗成功。
