Lapcharoen Kankanit, Bumrungpun Chunyaput, Chumpol Wiyada, Lunha Kamonwan, Yongkiettrakul Suganya, Lekcharoensuk Porntippa, Pruksakorn Chantima
Department of Microbiology and Immunology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.
Veterinary Diagnostic Laboratory, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.
Animals (Basel). 2025 Jul 30;15(15):2235. doi: 10.3390/ani15152235.
Feline urinary tract infections (UTIs) present a common challenge in veterinary practice, underscoring the importance of understanding local bacterial pathogens and antimicrobial resistance (AMR). This study determined bacterial prevalence and antimicrobial susceptibility in cats at Kasetsart University's Veterinary Teaching Hospital in Bangkok, Thailand. Of the 543 cystocentesis urine samples collected from 428 cats, 115 (21.2%) tested positive for bacterial cultures, leading to a diagnosis of UTIs in 95 cats (22.2%). The most prevalent isolates included (24.8%), species (19.2%), (13.6%), (12.0%), and species (12.0%). (8.8%) and (5.6%) were the predominant species. Rare pathogens such as and were also identified. Antimicrobial testing revealed alarming resistance, with 69.2% of isolates exhibiting multidrug resistance (MDR). and showed high resistance to amoxicillin/clavulanic acid (AMC) (45.2-70.6%) and sulfamethoxazole/trimethoprim (SXT) (51.6-52.9%). exhibited 85.7% resistance to AMC. Methicillin resistance was identified in 41.7% of isolates, particularly high in (75.0%) and (71.4%). High fluoroquinolone resistance among MDR isolates further exacerbates AMR concerns. These results indicate that MDR Gram-negative, , and species complicate the empirical treatment of feline UTIs, highlighting significant implications for AMR in veterinary practice.
猫泌尿系统感染（UTIs）是兽医临床中常见的挑战，凸显了了解当地细菌病原体和抗菌药物耐药性（AMR）的重要性。本研究确定了泰国曼谷 Kasetsart 大学兽医教学医院猫的细菌流行情况和抗菌药物敏感性。在从 428 只猫收集的 543 份膀胱穿刺尿液样本中，115 份（21.2%）细菌培养检测呈阳性，95 只猫（22.2%）被诊断为UTIs。最常见的分离株包括（24.8%）、种（19.2%）、（13.6%）、（12.0%）和种（12.0%）。（8.8%）和（5.6%）是主要的种。还鉴定出了罕见病原体如和。抗菌药物测试显示出令人担忧的耐药性，69.2%的分离株表现出多重耐药性（MDR）。和对阿莫西林/克拉维酸（AMC）（45.2 - 70.6%）和磺胺甲恶唑/甲氧苄啶（SXT）（51.6 - 52.9%）表现出高耐药性。对 AMC 表现出 85.7%的耐药性。在 41.7%的分离株中鉴定出耐甲氧西林，在（75.0%）和（71.4%）中尤其高。MDR 分离株中高氟喹诺酮耐药性进一步加剧了对 AMR 的担忧。这些结果表明，MDR 革兰氏阴性菌、和种使猫UTIs 的经验性治疗复杂化，凸显了兽医临床中 AMR 的重大影响。
