Roy L B, Edwards P A, Barr L H
JPEN J Parenter Enteral Nutr. 1985 Mar-Apr;9(2):170-2. doi: 10.1177/0148607185009002170.
The prevalence of malnutrition in Veterans Administration Hospitals has been well documented. Several methods have been proposed to assess nutritional status including prognostic nutritional index (PNI) and instant nutritional assessment (INA). A prospective study was done to evaluate the currently used nutritional assessments and determine their efficacy based on sensitivity and specificity in predicting surgical morbidity and mortality. Data on 46 patients were evaluated for the multiparameter index of PNI, total lymphocyte count and serum albumin for INA, and weight loss alone. In this analysis, intermediate and high risk PNI were combined as positive predictor of complications. Any abnormal value in INA was considered positive as was weight loss of greater than 6% of usual body weight. Sensitivity and specificity of each assessment method were determined by 2 X 2 contingency table, and significance of observed differences between methods was determined by chi 2 analysis. There were no complications or deaths in patients with less than 6% weight loss. All three patients with abnormal albumin and total lymphocyte count had complications as compared to only three of 32 patients when both of these parameters were normal. The PNI was also able to predict complications with an increasing incidence as the PNI increased. Only the difference between specificity of weight loss alone vs INA was statistically significant, p less than 0.05. Thus, weight loss alone can be used as a rapid, inexpensive assessment of nutritional status for predicting postoperative complications.
退伍军人管理局医院中营养不良的患病率已有充分记录。已经提出了几种评估营养状况的方法,包括预后营养指数(PNI)和即时营养评估(INA)。开展了一项前瞻性研究,以评估当前使用的营养评估方法,并根据预测手术发病率和死亡率的敏感性和特异性来确定其有效性。对46例患者的数据进行了评估,包括PNI的多参数指数、INA的总淋巴细胞计数和血清白蛋白,以及仅体重减轻情况。在该分析中,将中度和高度风险的PNI合并作为并发症的阳性预测指标。INA中的任何异常值以及体重减轻超过通常体重的6%均被视为阳性。每种评估方法的敏感性和特异性通过2×2列联表确定,方法之间观察到的差异的显著性通过卡方分析确定。体重减轻少于6%的患者未出现并发症或死亡。白蛋白和总淋巴细胞计数异常的所有3例患者均出现并发症,而这两个参数均正常的32例患者中只有3例出现并发症。随着PNI升高,PNI也能够预测并发症,且发病率增加。仅体重减轻与INA的特异性之间的差异具有统计学意义,p小于0.05。因此,仅体重减轻可作为一种快速、廉价的营养状况评估方法,用于预测术后并发症。