Xiao Hui, Baxter G David, Liu Lizhou, Hoeta Tobias, Wibowo Erik
Centre for Men's Health NZ, Centre for Health, Activity and Rehabilitation Research, School of Physiotherapy, University of Otago, PO Box 56, Dunedin, 9054, New Zealand.
Exercise Oncology Lab, Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, Canada.
Support Care Cancer. 2025 May 20;33(6):483. doi: 10.1007/s00520-025-09521-7.
Prostate cancer treatment can lead to significant long-term side effects that impact patients' quality of life and supportive care needs (SCN). This study explores the associations between quality of life (QoL) and SCN among prostate cancer survivors, with a focus on the impact of treatment received, care service utilization, and the differences between Māori and non-Māori patients.
Random stratified sampling data were collected from 1075 prostate cancer survivors who were diagnosed within the past 5 years. Hierarchical regression analyses examined the associations between QoL domains and SCN, adjusting for demographic, clinical, and treatment-related factors. LASSO (Least Absolute Shrinkage and Selection Operator) was used to select variables to test the interaction effects of different treatments.
Significant disparities were found between Māori and non-Māori patients in physical and mental health scores, care service utilization, and overall SCN. Māori men had lower scores in these areas. Most QoL domains were negatively associated with more SCN, particularly mental health and hormonal issues. Androgen deprivation therapy (ADT) exacerbates some negative effects of poor mental health and hormonal issues for non-Māori, while the use of care services and radical prostatectomy (RP) was associated with mitigating SCN for Māori patients.
This study highlights the complex interplay between QoL, SCN, and treatment modalities among prostate cancer survivors in New Zealand. The findings underscore the need for culturally tailored supportive care services to address the unique needs of Māori patients.
前列腺癌治疗可导致严重的长期副作用，影响患者的生活质量和支持性护理需求（SCN）。本研究探讨前列腺癌幸存者的生活质量（QoL）与SCN之间的关联，重点关注所接受治疗的影响、护理服务利用情况以及毛利族和非毛利族患者之间的差异。
从过去5年内确诊的1075名前列腺癌幸存者中收集随机分层抽样数据。分层回归分析检验了生活质量领域与SCN之间的关联，并对人口统计学、临床和治疗相关因素进行了调整。使用最小绝对收缩和选择算子（LASSO）选择变量，以测试不同治疗的交互作用。
毛利族和非毛利族患者在身心健康评分、护理服务利用情况和总体SCN方面存在显著差异。毛利族男性在这些方面得分较低。大多数生活质量领域与更多的SCN呈负相关，尤其是心理健康和激素问题。雄激素剥夺疗法（ADT）加剧了非毛利族心理健康不佳和激素问题的一些负面影响，而使用护理服务和根治性前列腺切除术（RP）与减轻毛利族患者的SCN相关。
本研究强调了新西兰前列腺癌幸存者的生活质量、SCN和治疗方式之间的复杂相互作用。研究结果强调需要提供符合文化特点的支持性护理服务，以满足毛利族患者的独特需求。
