Guaza C, Borrell S
Pharmacol Biochem Behav. 1985 Mar;22(3):357-60. doi: 10.1016/0091-3057(85)90031-0.
Ethanol was administered to rats by means of a liquid diet for 16 days; after an ethanol-free interval of four weeks, animals received a test (IP) dose of ethanol (2 g/kg), and the adrenocortical and adrenomedullary responses were evaluated. Chronically ethanol-exposed animals showed tolerance to the stimulatory effect of ethanol in the pituitary-adrenal axis. Likewise, previously dependent rats showed tolerance to the increase in the activity of the adrenomedullary function induced by acute administration of the drug. Our results indicate that chronic ethanol ingestion can induce persistent changes after complete alcohol abstinence.
通过液体饮食给大鼠喂食乙醇，持续16天；在四周无乙醇的间隔期后，给动物腹腔注射（IP）一次乙醇测试剂量（2 g/kg），并评估肾上腺皮质和肾上腺髓质的反应。长期接触乙醇的动物对乙醇在垂体-肾上腺轴中的刺激作用表现出耐受性。同样，先前有依赖性的大鼠对急性给药该药物引起的肾上腺髓质功能活动增加也表现出耐受性。我们的结果表明，长期摄入乙醇在完全戒酒之后仍可诱导持续的变化。
