Clina Julianne G, Danon Jessica C, Helsel Brian C, Lepping Rebecca J, Martin Laura E, Sherman Joseph R, Brucks Morgan G, Donnelly Joseph E, Ptomey Lauren T
Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.
Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Alzheimers Dement. 2025 May;21(5):e70297. doi: 10.1002/alz.70297.
Resting-state functional connectivity (FC) of the default mode network (DMN) is linked to Alzheimer's disease in people with Down syndrome (DS). In adults without DS, cardiorespiratory fitness is associated with DMN FC; however, this has not been unexplored in DS.
This analysis used baseline data from an intervention in adults with DS. Resting-state functional magnetic resonance imaging measured connectivity from the posterior cingulate cortex seed to DMN nodes. Fitness was measured by the maximal treadmill test. Pearson correlations and linear regressions were used to examine the associations between fitness and FC.
Data from 40 adults with DS (26.0 years, 58% female) showed fitness was associated with overall DMN connectivity (r = 0.472, p = 0.004) and medial prefrontal cortex connectivity (r = 0.431, p = 0.010). The association between fitness and DMN FC remained significant after adjustment for age and sex (β = 0.0072, p = 0.04).
Fitness may be associated with DMN FC in DS.
In adults with DS, cardiorespiratory fitness was associated with overall DMN connectivity, which remained significant after adjusting for age and sex. No associations were found between moderate to vigorous physical activity and DMN connectivity. Increasing fitness may be a therapeutic strategy for AD prevention or delay in DS.
默认模式网络（DMN）的静息态功能连接（FC）与唐氏综合征（DS）患者的阿尔茨海默病有关。在没有DS的成年人中，心肺适能与DMN的FC相关；然而，这在DS患者中尚未得到充分研究。
本分析使用了对成年DS患者进行干预的基线数据。静息态功能磁共振成像测量了从后扣带回皮质种子点到DMN节点的连接性。通过最大跑步机测试来测量适能。使用Pearson相关性分析和线性回归来检验适能与FC之间的关联。
40名成年DS患者（年龄26.0岁，58%为女性）的数据显示，适能与整体DMN连接性（r = 0.472，p = 0.004）以及内侧前额叶皮质连接性（r = 0.431，p = 0.010）相关。在对年龄和性别进行调整后，适能与DMN的FC之间的关联仍然显著（β = 0.0072，p = 0.04）。
适能可能与DS患者的DMN的FC有关。
在成年DS患者中，心肺适能与整体DMN连接性相关，在对年龄和性别进行调整后该相关性仍然显著。未发现中度至剧烈身体活动与DMN连接性之间存在关联。提高适能可能是预防或延缓DS患者患AD的一种治疗策略。
