认知功能稳定的唐氏综合征成年人默认模式网络的连接性改变：“加速衰老”还是阿尔茨海默病的前奏？
Altered connectivity of the default mode network in cognitively stable adults with Down syndrome: "Accelerated aging" or a prelude to Alzheimer's disease?
作者信息
Rosas H Diana, Lewis Lydia R, Mercaldo Nathaniel D, Nasr Shahin, Brickman Adam M, Siless Viviana, Yassa Michael, Sathishkumar Mithra, Lott Ira, Schupf Nicole, Silverman Wayne, Lai Florence
机构信息
Department of Neurology Massachusetts General Hospital Harvard Medical School Boston Massachusetts USA.
Department of Radiology Athinoula Martinos Center Massachusetts General Hospital Harvard Medical School Charlestown Massachusetts USA.
出版信息
Alzheimers Dement (Amst). 2021 May 20;13(1):e12105. doi: 10.1002/dad2.12105. eCollection 2021.
INTRODUCTION
Most individuals with Down syndrome (DS) have the neuropathological changes of Alzheimer's disease (AD) by age 40 and will have developed dementia by age 60. Alterations of the intrinsic connectivity of the default mode network (DMN) are associated with AD in the neurotypical population. In this study, we sought to determine whether, and how, connectivity between the hubs of the DMN were altered in cognitively stable adults with DS who did not have evidence of either mild cognitive impairment or AD.
METHODS
Resting state functional MRI scans were collected from 26 healthy adults with DS and 26 healthy age-matched non-DS controls. Nodes comprising the DMN were generated as ROI's (regions of interest) and inter-nodal correlations estimated.
RESULTS
Analysis of intra-network connectivity of the DMN revealed anterior-posterior DMN dissociation and hyper- and hypo-connectivity, suggesting "accelerated aging" in DS.
DISCUSSION
Disruption of the DMN may serve as a prelude for AD in DS.
引言
大多数唐氏综合征（DS）患者在40岁时会出现阿尔茨海默病（AD）的神经病理学变化，并在60岁时发展为痴呆症。在神经典型人群中，默认模式网络（DMN）的内在连接改变与AD相关。在本研究中，我们试图确定在没有轻度认知障碍或AD证据的认知稳定的DS成年患者中，DMN枢纽之间的连接是否以及如何发生改变。
方法
对26名患有DS的健康成年人和26名年龄匹配的健康非DS对照者进行静息态功能磁共振成像扫描。将构成DMN的节点生成为感兴趣区域（ROI），并估计节点间相关性。
结果
对DMN的网络内连接性分析显示DMN前后分离以及连接增强和减弱，提示DS存在“加速衰老”。
讨论
DMN的破坏可能是DS发生AD的前奏。
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