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2型糖尿病患者糖尿病周围神经病变的综合风险分析

Comprehensive risk analysis of diabetic peripheral neuropathy in type II diabetes mellitus.

作者信息

Contesa Alex, Malini Hema, Rahman Dally

机构信息

Graduate Student Program, Faculty of Nursing, Universitas Andalas, Kampus Unand Limau Manis, Padang, West Sumatra 25163 Indonesia.

Faculty of Health and Sciences, Universitas Mercubaktijaya, Padang, Indonesia.

出版信息

J Diabetes Metab Disord. 2025 May 18;24(1):123. doi: 10.1007/s40200-025-01630-8. eCollection 2025 Jun.

Abstract

OBJECTIVE

Type II diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia resulting from impaired insulin secretion, action, or both. Diabetic peripheral neuropathy is among the most common complications of disease, with its incidence linked to various risk factors. This study aims to evaluate the risk factors associated with peripheral neuropathy among patients with Diabetes Mellitus in Padang City.

METHOD

Using a descriptive, cross-sectional design with stratified random sampling, 390 T2DM patients were assessed. Research instruments included the Global Physical Activity Questionnaire, the Patient Health Questionnaire-9, and the Michigan Neuropathy Screening Instrument. Data analysis employed chi-square tests and multiple logistic regression.

RESULTS

The findings revealed significant associations between Diabetic peripheral neuropathy and factors such as diabetes duration, socioeconomic status, smoking, glycemic control, dyslipidemia, physical activity, and depressive symptoms ( < 0.05). Conversely, no significant relationship was observed for sex or hypertension ( > 0.05). Dyslipidemia emerged as Diabetic peripheral neuropathy's most influential risk factor ( = 0.000, OR = 3.295).

CONCLUSION

This study emphasizes the importance of early detection through routine screening and regular follow-up care. Targeting modifiable risk factors through health education and improved disease management strategies could significantly reduce the burden of Diabetic peripheral neuropathy among Type 2 Diabetes Mellitus patients.

摘要

目的

2型糖尿病是一种代谢紊乱疾病,其特征为胰岛素分泌受损、作用异常或两者兼而有之导致的慢性高血糖。糖尿病周围神经病变是该疾病最常见的并发症之一,其发病率与多种风险因素相关。本研究旨在评估巴东市糖尿病患者中与周围神经病变相关的风险因素。

方法

采用描述性横断面设计和分层随机抽样方法,对390例2型糖尿病患者进行评估。研究工具包括全球体力活动问卷、患者健康问卷-9和密歇根神经病变筛查工具。数据分析采用卡方检验和多元逻辑回归。

结果

研究结果显示,糖尿病周围神经病变与糖尿病病程、社会经济状况、吸烟、血糖控制、血脂异常、体力活动和抑郁症状等因素之间存在显著关联(P<0.05)。相反,未观察到性别或高血压与糖尿病周围神经病变之间存在显著关系(P>0.05)。血脂异常是糖尿病周围神经病变最具影响力的风险因素(P=0.000,OR=3.295)。

结论

本研究强调了通过常规筛查和定期随访进行早期检测的重要性。通过健康教育和改进疾病管理策略针对可改变的风险因素,可显著减轻2型糖尿病患者糖尿病周围神经病变的负担。

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本文引用的文献

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New perspectives in diabetic neuropathy.糖尿病性神经病变的新视角。
Neuron. 2023 Sep 6;111(17):2623-2641. doi: 10.1016/j.neuron.2023.05.003. Epub 2023 May 31.
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Predicting diabetic nephropathy in type 2 diabetic patients using machine learning algorithms.使用机器学习算法预测2型糖尿病患者的糖尿病肾病
J Diabetes Metab Disord. 2022 Jul 26;21(2):1433-1441. doi: 10.1007/s40200-022-01076-2. eCollection 2022 Dec.
5
Depression Symptoms in Patients with Diabetic Peripheral Neuropathy.糖尿病周围神经病变患者的抑郁症状。
Rev Diabet Stud. 2020;16(1):35-40. doi: 10.1900/RDS.2020.16.35. Epub 2020 Dec 28.
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Current Strategies for the Management of Painful Diabetic Neuropathy.目前治疗糖尿病性神经痛的策略。
J Diabetes Sci Technol. 2022 Mar;16(2):341-352. doi: 10.1177/1932296820951829. Epub 2020 Aug 28.

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