Aleidan Fahad A S, Ahmad Banderi A, Alotaibi Farah A, Aleesa Dalal H, Alhefdhi Nuha A, Badri Motasim, Abdel Gader Abdel Galil
College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
College of Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
Int J Gen Med. 2020 Oct 16;13:881-889. doi: 10.2147/IJGM.S273807. eCollection 2020.
To determine the prevalence and the risk factors of diabetic peripheral neuropathy (DPN) in hospitalized adult Saudi diabetics.
This is a retrospective, nested case-control study conducted at King Abdulaziz Medical City (KAMC) in Riyadh, Saudi Arabia. All diabetic patients admitted to the hospital between the January 1, and December 31, 2018 were considered for inclusion in the study. Patients with DPN were identified and three controls per case were randomly selected from the remaining diabetic patients without peripheral neuropathy (PN).
A total of 2,096 adult diabetic patients were identified during the study period. Of these, 73 patients (3.5%) were confirmed to be suffering from DPN and 219 were included as controls. When comparing diabetic with the control cases, DPN cases were significantly older (=0.002), had a significantly higher proportion of type 2 diabetes (=0.023), chronic kidney disease (<0.0001), cerebral vascular stroke (=0.027), hypertension (=0.005), dyslipidemia (=0.002), peripheral vascular disease (<0.0001), osteoarthritis (=0.034), diabetic ketoacidosis (=0.003), foot ulcers (=0.006), gangrene (=0.001), lower limb ischemia (=0.001), increased duration with diabetic disease (=0.031), increased BMI (=0.003), higher serum creatinine (<0.001) and lower serum albumin levels (=0.035). In the multivariate logistic regression, only older age {odds ratio (OR) 1.02, 95% CI 1.01-1.04, =0.031}, chronic kidney disease (OR 2.39, 95% CI 1.23-4.64, =0.010) and peripheral vascular disease (OR 3.14, 95% CI 1.39-7.13, =0.006) were independently associated with DPN.
This study identified several risk factors that contributed to the development of DPN in Saudis. These must be considered in strategies and campaigns aimed at risk reduction of cardiovascular and chronic diseases, and consequently progression of DPN.
确定沙特成年住院糖尿病患者中糖尿病周围神经病变（DPN）的患病率及危险因素。
这是一项在沙特阿拉伯利雅得阿卜杜勒阿齐兹国王医疗城（KAMC）进行的回顾性巢式病例对照研究。纳入2018年1月1日至12月31日期间入院的所有糖尿病患者。识别出DPN患者，并从其余无周围神经病变（PN）的糖尿病患者中为每例患者随机选取3名对照。
研究期间共识别出2096例成年糖尿病患者。其中，73例（3.5%）确诊患有DPN，219例被纳入对照组。将糖尿病患者与对照病例进行比较时，DPN病例年龄显著更大（P = 0.002），2型糖尿病比例显著更高（P = 0.023），慢性肾病（P < 0.0001）、脑血管卒中（P = 0.027）、高血压（P = 0.005）、血脂异常（P = 0.002）、周围血管疾病（P < 0.0001）、骨关节炎（P = 0.034）、糖尿病酮症酸中毒（P = 0.003）、足部溃疡（P = 0.006）、坏疽（P = 0.001）、下肢缺血（P = 0.001）、糖尿病病程延长（P = 0.031）、BMI增加（P = 0.003）、血清肌酐升高（P < 0.001）及血清白蛋白水平降低（P = 0.035）。在多因素逻辑回归分析中，只有年龄较大（比值比[OR] 1.02，95%可信区间[CI] 1.01 - 1.04，P = 0.031）、慢性肾病（OR 2.39，95% CI 1.23 - 4.64，P = 0.010）和周围血管疾病（OR 3.14，95% CI 1.39 - 7.13，P = 0.006）与DPN独立相关。
本研究确定了沙特人DPN发生的几种危险因素。在旨在降低心血管疾病和慢性疾病风险从而降低DPN进展风险的策略和活动中必须考虑这些因素。
