Stempels Femmy C, van den Bogaart Geert
Department of Molecular Immunology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, the Netherlands.
Autophagy Rep. 2022 Mar 22;1(1):25-28. doi: 10.1080/27694127.2022.2040765. eCollection 2022.
The process of LC3-associated phagocytosis (LAP) combines elements of phagocytosis and autophagy. LAP is involved in clearance of pathogens and cell debris, antigen presentation, and immune signaling. However, the mechanistic role of LAP is incompletely understood. Based on observations from our recent study, we propose that LAP might serve as a sorting mechanism to cluster proteins destined for degradation into discrete domains of the phagosomal membrane.
LC3相关吞噬作用（LAP）过程融合了吞噬作用和自噬作用的元素。LAP参与病原体和细胞碎片的清除、抗原呈递及免疫信号传导。然而，LAP的机制作用尚未完全明确。基于我们近期研究的观察结果，我们提出LAP可能作为一种分选机制，将注定要降解的蛋白质聚集到吞噬体膜的离散区域。
