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远端吻合口新的入口撕裂可预测DeBakey I型主动脉夹层半弓修复术后的长期预后†

Distal anastomotic new entry tears predict long-term outcomes after hemi-arch repair for DeBakey I aortic dissection†.

作者信息

Marway Prabhvir S, Campello Jorge Carlos A, Ahmad Rana-Armaghan, Tjahjadi Nicasius, Patel Himanshu J, Yang Bo, Burris Nicholas S

机构信息

Department of Radiology, University of Michigan, Ann Arbor, MI, USA.

Department of Cardiac Surgery, University of Michigan, Ann Arbor, MI, USA.

出版信息

Eur J Cardiothorac Surg. 2025 Jun 3;67(6). doi: 10.1093/ejcts/ezaf170.

Abstract

OBJECTIVES

Aortic arch tears, including distal anastomosis new entry tears and residual arch tears, have been associated with adverse outcomes (false lumen growth, distal reoperation) after hemi-arch repair for DeBakey Type I aortic dissection. However, no study has compared distal anastomosis new entry tears and RATs as independent entities despite their distinct aetiologies and preventative strategies which may inform surgical management.

METHODS

Retrospective cohort study of adult patients with hemi-arch repair for DeBakey Type I aortic dissection at a tertiary referral centre (1996-2021). We included patients who survived beyond their initial hospitalization with good-quality post-operative CT angiograms. Distal anastomosis new entry tears and residual arch tears metrics were collected from the first good-quality post-operative CT. Maximal aortic diameters (distal to graft) were collected from pre- and post-hemi-arch repair CT angiograms. Presence and imaging characteristics of distal anastomosis new entry tears and RATs were examined for prediction of false lumen growth and distal aortic intervention.

RESULTS

We included 272 patients, and 24.5% (69) had distal anastomosis new entry tears, which on multivariable analysis was associated with a post-operative descending diameter change of +6.2 mm (95% confidence interval [CI]: 4.5, 7.9) and greater risk of distal intervention, hazard ratio 3.24 (95% CI: 1.57, 6.68); residual arch tears were not significantly associated, hazard ratio 0.72 (95% CI: 0.28, 1.83). Distal anastomosis new entry tears located on the greater curvature versus lesser curvature (58% vs 42%, P = 0.044) were more likely to lead to reoperation (45% vs 17%, P = 0.033).

CONCLUSIONS

Distal anastomosis new entry tears, not residual arch tears, correlate strongly with negative descending aorta remodelling and distal intervention after hemi-arch repair for DeBakey I aortic dissection. Therefore, additional strategies are warranted to prevent distal anastomosis new entry tears, a result of anastomotic technical challenge, during operative repair.

摘要

目的

主动脉弓撕裂,包括远端吻合口新破口和残余弓部撕裂,与Debakey I型主动脉夹层半弓修复术后的不良结局(假腔扩大、远端再次手术)相关。然而,尽管远端吻合口新破口和残余弓部撕裂的病因和预防策略不同,可能为手术管理提供依据,但尚无研究将二者作为独立个体进行比较。

方法

对一家三级转诊中心(1996 - 2021年)接受Debakey I型主动脉夹层半弓修复术的成年患者进行回顾性队列研究。我们纳入了术后首次高质量CT血管造影检查时存活且出院的患者。从首次高质量术后CT中收集远端吻合口新破口和残余弓部撕裂的指标。从半弓修复术前和术后的CT血管造影中收集最大主动脉直径(移植物远端)。检查远端吻合口新破口和残余弓部撕裂的存在情况及影像学特征,以预测假腔扩大和远端主动脉干预。

结果

我们纳入了272例患者,24.5%(69例)有远端吻合口新破口,多变量分析显示其与术后降主动脉直径变化+6.2 mm相关(95%置信区间[CI]:4.5,7.9),且远端干预风险更高,风险比为3.24(95% CI:1.57,6.68);残余弓部撕裂无显著相关性,风险比为0.72(95% CI:0.28,1.83)。位于大弯侧而非小弯侧的远端吻合口新破口(58%对42%,P = 0.044)更可能导致再次手术(45%对17%,P = 0.033)。

结论

对于Debakey I型主动脉夹层半弓修复术,远端吻合口新破口而非残余弓部撕裂与降主动脉不良重塑和远端干预密切相关。因此,在手术修复过程中,有必要采取额外策略来预防远端吻合口新破口,这是吻合技术挑战导致的结果。

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