Song Wenjing, Wang Yansu, Kong Yu, Yang Jingwen, Ji Ying, Sun Xiaosa, Yuan Xinyi, Li Xiaowen, Tian Jin, Yang Fei, Xie Shao, Chen Hao
Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Jiangsu, China.
Graduate School, Xuzhou Medical University, Jiangsu, China.
Neurol Sci. 2025 May 21. doi: 10.1007/s10072-025-08197-5.
This study aims to examine clinical, laboratory, neuroimaging and perinatal differences between pregnant women with isolated PRES and those with concurrent HELLP syndrome, thus improving clinicians' understanding of these conditions.
A cross-sectional analysis was performed on 60 pregnant and postpartum women diagnosed with PRES at the Affiliated Hospital of Xuzhou Medical University, spanning from January 2014 to March 2024. These patients were divided into two groups based on laboratory findings: the isolated PRES group and the PRES-HELLP group. The study compared general clinical parameters (risk factors, neurological symptoms), laboratory tests, neuroimaging data (affected brain regions), and perinatal outcomes between the two groups.
The study included 40 patients with isolated PRES and 20 patients with PREScombined with HELLP syndrome. Patients in the PRES-HELLP group exhibited lower platelet count, platelet-to-lymphocyte ratio (PLR), serum albumin (ALB), serum sodium ion (Na), serum total calcium ion (Ca), and Apgar scores (both at 1 and 5 min), along with elevated CRP, liver enzymes, and urea levels compared to those in the PRES group (P < 0.05).
Concurrent HELLP syndrome exacerbates maternal and fetal risks in pregnant women with PRES, emphasizing the significance of prompt recognition.
本研究旨在探讨孤立性产后急性肾损伤（PRES）孕妇与并发HELLP综合征孕妇在临床、实验室检查、神经影像学及围产期方面的差异，从而提高临床医生对这些病症的认识。
对2014年1月至2024年3月在徐州医科大学附属医院诊断为PRES的60例孕妇及产后妇女进行横断面分析。根据实验室检查结果将这些患者分为两组：孤立性PRES组和PRES-HELLP组。研究比较了两组之间的一般临床参数（危险因素、神经症状）、实验室检查、神经影像学数据（受影响的脑区）及围产期结局。
该研究纳入了40例孤立性PRES患者和20例合并HELLP综合征的PRES患者。与PRES组相比，PRES-HELLP组患者的血小板计数、血小板与淋巴细胞比值（PLR）、血清白蛋白（ALB）、血清钠离子（Na）、血清总钙离子（Ca）及阿氏评分（1分钟和5分钟时）均较低，而CRP、肝酶及尿素水平升高（P<0.05）。
并发HELLP综合征会加重PRES孕妇的母婴风险，强调了及时识别的重要性。
