Pierce Jordan E, Neta Maital
Department of Psychology & Center for Brain, Biology, and Behavior, University of Nebraska-Lincoln, Lincoln, NE 68588-0156, United States.
Soc Cogn Affect Neurosci. 2025 Jan 18;20(1). doi: 10.1093/scan/nsaf055.
Cognitive reappraisal is a form of emotion regulation that involves the reinterpretation of stimuli to change one's emotional state, often to reduce negative affect. Emotion regulation functional magnetic resonance imaging (fMRI) tasks generally yield increased activation in prefrontal cortex and, less consistently, decreased amygdala activation. Only a few studies, however, have examined how intrinsic brain organization, characterized via resting-state fMRI, relates to reappraisal, typically focusing on the same task-derived brain regions. Here, we administered an emotion regulation task where participants (n = 227, 6-80 years) viewed or downregulated responses to negative images, then completed a resting-state fMRI scan. We examined the functional connectivity in 300 whole-brain regions of interest comprising 13 functional networks. We found that the network segregation, or relative balance of within- and between-network connectivity, in the default mode network (DMN), dorsal attention network (DAN), and somatomotor-dorsal (SMd) network was associated with reappraisal success (controlling for age and movement). Specifically, greater connectivity within the DMN and DAN, lower connectivity within the SMd, and greater connectivity between the SMd and lateral SM networks predicted better reappraisal ability. These networks also partially overlapped with brain areas supporting emotion regulation and reactivity, suggesting that functional brain organization is a key factor in shaping emotion regulation across the lifespan.
认知重评是一种情绪调节形式，它涉及对刺激进行重新解释以改变一个人的情绪状态，通常是为了减少负面影响。情绪调节功能磁共振成像（fMRI）任务一般会使前额叶皮层的激活增加，而杏仁核激活减少的情况则不太一致。然而，只有少数研究考察了通过静息态fMRI表征的内在脑组织结构与重评之间的关系，这些研究通常聚焦于相同的源自任务的脑区。在此，我们实施了一项情绪调节任务，让参与者（n = 227，年龄6至80岁）观看负面图像或下调对负面图像的反应，然后完成一次静息态fMRI扫描。我们考察了包含13个功能网络的300个全脑感兴趣区域的功能连接。我们发现，默认模式网络（DMN）、背侧注意网络（DAN）和躯体运动-背侧（SMd）网络中的网络隔离，即网络内和网络间连接的相对平衡，与重评成功相关（控制了年龄和运动因素）。具体而言，DMN和DAN内更强的连接、SMd内较弱的连接以及SMd与外侧SM网络之间更强的连接预示着更好的重评能力。这些网络还部分重叠于支持情绪调节和反应性调节的脑区，这表明功能性脑组织结构是塑造整个生命周期情绪调节的关键因素。
