Osei Duah Junior Isaiah, Akuffo Kwadwo Owusu, Ampong Josephine, Owiredu David, Boateng Bridget Senya, Danso-Appiah Anthony
Department of Optometry and Visual Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Department of Epidemiology and Disease Control, School of Public Health, University of Ghana, Accra, Legon, Ghana.
PLoS One. 2025 May 21;20(5):e0320030. doi: 10.1371/journal.pone.0320030. eCollection 2025.
Evidence linking diet and ocular diseases is growing, yet variations persist, with a paucity of data in sub-Saharan Africa. The proposed review will systematically synthesize evidence on dietary factors associated with predominant eye disorders (cataracts, refractive error, glaucoma, diabetic retinopathy, age-related macular degeneration, and dry eye disease) in the sub-Saharan African population. The systematic review protocol will follow PRISMA-P (Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols) for transparency in reporting. All relevant published studies in the English Language will be identified from PubMed, Scopus, Web of Science, Embase, Health Inter-Network Access to Research Initiative (HINARI), Cumulative Index to Nursing and Allied Health Literature (CINAHL), African Journal of Science, and Cochrane Central Register of Controlled Trials (CENTRAL) using medical subject headings (MeSH) and controlled vocabulary without date restrictions. The reference lists of all retrieved studies will be checked and experts will be contacted for additional relevant studies. The risk of bias for observational studies will be assessed using ROBINS-E (Risk of Bias in Non-Randomized Studies - of Exposure) and for non-interventional and randomized studies ROBINS-V2 (Risk of Bias in Non-Randomized Studies version 2) and ROB2 (Cochrane Risk of Bias 2) will be employed respectively. Study quality will be assessed using the National Heart Lung and Blood Institutes Quality Assessment (NHLBI) tool for Observational Cohort and Cross-Sectional Studies and Controlled Interventional Studies. Meta-analysis will not be considered because of the wide range of dietary factors and the susceptibility to high heterogeneity. Patterns of association between dietary factors and the specific eye diseases will be consolidated by Synthesis Without Meta-analysis (SWiM).
将饮食与眼部疾病联系起来的证据越来越多,但差异仍然存在,撒哈拉以南非洲地区的数据匮乏。拟议的综述将系统地综合关于撒哈拉以南非洲人群中与主要眼部疾病(白内障、屈光不正、青光眼、糖尿病视网膜病变、年龄相关性黄斑变性和干眼症)相关的饮食因素的证据。系统综述方案将遵循PRISMA-P(系统评价和Meta分析方案的首选报告项目)以提高报告的透明度。将使用医学主题词(MeSH)和控制词汇,在没有日期限制的情况下,从PubMed、Scopus、科学网、Embase、健康研究网络访问倡议(HINARI)、护理及相关健康文献累积索引(CINAHL)、《非洲科学杂志》和Cochrane对照试验中央注册库(CENTRAL)中识别所有以英文发表的相关研究。将检查所有检索到的研究的参考文献列表,并联系专家获取其他相关研究。对于观察性研究,将使用ROBINS-E(非随机研究中的暴露偏倚风险)评估偏倚风险,对于非干预性和随机研究,将分别使用ROBINS-V2(非随机研究中的偏倚风险第2版)和ROB2(Cochrane偏倚风险2)。将使用美国国立心肺血液研究所观察性队列和横断面研究以及对照干预性研究的质量评估(NHLBI)工具评估研究质量。由于饮食因素范围广泛且易出现高度异质性,因此不考虑进行Meta分析。饮食因素与特定眼部疾病之间的关联模式将通过非Meta分析综合(SWiM)进行整合。