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[尿道细胞学研究在尿失禁中的应用价值]

[Usefulness of urethrocytologic studies in urinary incontinence].

作者信息

Fischer W, Hannig I

出版信息

Zentralbl Gynakol. 1985;107(7):424-31.

PMID:4039871
Abstract

Comparative cytological studies were conducted in urethra and vagina of 40 women with stress incontinence, another 40 with urge incontinence and 53 clinically intact women for morphological assessment of urinary incontinence. Evaluation was based on maturation index, maturation value, and dynamic estrogenicity index. During sexual maturity no significant difference regarding proliferability of urethral and vaginal epithelium was found existing between clinically intact women and patients with stress or urge incontinence. Differences of maturation values above 30 between urethral and vaginal cells were recordable only from post-menopause patients with urge incontinence, providing for certain possible conclusions as to the form of urinary incontinence. However, in post-menopause patients, oral and vaginal estriol therapy was followed by significant rise in intermedial and superficial cells in both organs. Improvement of stress and urge incontinence was recordable subjectively also from estriol therapy during sexual maturity, independent from urethral or vaginal cell patterns. Hence, urethral cytology is only conditionally suitable for differential diagnosis and optimization of therapy of urinary incontinence. Primarily it is suitable to coping for disturbances of micturition with an uncharacteristic urinary urge symptomatology or chronic urethritis.

摘要

对40名压力性尿失禁女性、另外40名急迫性尿失禁女性以及53名临床无异常的女性的尿道和阴道进行了比较细胞学研究,以对尿失禁进行形态学评估。评估基于成熟指数、成熟值和动态雌激素指数。在性成熟期,临床无异常的女性与压力性或急迫性尿失禁患者之间,尿道和阴道上皮的增殖能力未发现显著差异。仅在绝经后急迫性尿失禁患者中,可记录到尿道和阴道细胞成熟值相差超过30,这为尿失禁的形式提供了某些可能的结论。然而,在绝经后患者中,口服和阴道使用雌三醇治疗后,两个器官的中层和表层细胞均显著增加。在性成熟期,主观上也可记录到雌三醇治疗对压力性和急迫性尿失禁的改善,这与尿道或阴道细胞模式无关。因此,尿道细胞学仅在一定条件下适用于尿失禁的鉴别诊断和治疗优化。它主要适用于应对具有非特异性尿急症状或慢性尿道炎的排尿障碍。

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