van Oorschot Hanneke Doremiek, Hardillo Jose Angelito, Baatenburg de Jong Robert Jan
Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer Center, Rotterdam, The Netherlands
Scientific Bureau, Dutch Institute for Clinical Auditing, Leiden, The Netherlands.
BMJ Open. 2025 May 21;15(5):e092467. doi: 10.1136/bmjopen-2024-092467.
The Dutch Head and Neck Audit-Oral Cavity (DHNA-OC) cohort was collected to study the quality of care, current treatment and survival for oral cavity cancer (OCC) across all hospitals treating head and neck cancer (HNC) in the Netherlands.
The DHNA-OC is a registry-based national cohort of 2545 first primary OCC patients treated with curative intent between 2018 and 2021. All 14 HNC hospitals in the Netherlands contributed, guaranteeing national coverage. The DHNA-OC cohort is an elaborate dataset including variables on patient and tumour characteristics, treatment, complications, recurrence rates and survival.
The median age at diagnosis was 67 years and most tumours were early stage (cT1 in 32% and cT2 in 31%). Tongue tumours were most common, and surgery was performed in 91.3% of the patients. The number of included patients per hospital varied from 82 to 367. The proportion of advanced tumour stage varied significantly between hospitals. Substantial data completeness was acquired with only two variables exceeding 10% missing (comorbidities and performance score).
The DHNA-OC cohort will be used to study benchmarking of and current knowledge gaps in OCC care. Collaboration with other institutions or national/regional databases is highly encouraged. Some examples of planned studies are the assessment of hospital variation in outcome indicators for surgery and population-based treatment effects. The results of these studies will be used to identify best practices and continue improving the quality of care. Longitudinal cohort follow-up and enrolment will continue prospectively.
收集荷兰头颈癌审计-口腔癌（DHNA-OC）队列，以研究荷兰所有治疗头颈癌（HNC）的医院中口腔癌（OCC）的护理质量、当前治疗方法和生存率。
DHNA-OC是一个基于登记处的全国性队列，包含2018年至2021年间接受根治性治疗的2545例原发性OCC患者。荷兰所有14家HNC医院均有参与，确保了全国覆盖范围。DHNA-OC队列是一个详尽的数据集，包括患者和肿瘤特征、治疗、并发症、复发率和生存率等变量。
诊断时的中位年龄为67岁，大多数肿瘤处于早期阶段（32%为cT1期，31%为cT2期）。舌部肿瘤最为常见，91.3%的患者接受了手术治疗。每家医院纳入的患者数量从82例到367例不等。不同医院之间晚期肿瘤阶段的比例差异显著。数据完整性较高，只有两个变量的缺失率超过10%（合并症和体能状态评分）。
DHNA-OC队列将用于研究OCC护理的基准和当前的知识差距。强烈鼓励与其他机构或国家/地区数据库开展合作。计划开展的研究示例包括评估手术结局指标的医院差异以及基于人群的治疗效果。这些研究结果将用于确定最佳实践，并持续提高护理质量。队列的纵向随访和入组将继续前瞻性地进行。
